KCNH3 - potassium voltage-gated channel subfamily H member 3 Gene

Also Known as BEC1; ELK2; Kv12.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23416

About KCNH3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,539,030-49,558,337 (from NCBI)

This gene has 5 transcripts (splice variants), 233 orthologues and 17 paralogues. Biased expression in brain (RPKM 7.0), testis (RPKM 0.9) and 2 other tissues.

Summary

The protein encoded by this gene is a voltage-gated Potassium Channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

KCNH3 Products (2)

mRNA	Protein	Name
NM_001314030.2	NP_001300959.1	potassium voltage-gated channel subfamily H member 3 isoform 2
NM_012284.3	NP_036416.1	potassium voltage-gated channel subfamily H member 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	10455180	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20638388	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in potassium ion transport	IDA IDA: Inferred from direct assay	10455180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNH3 Protein Structure

PAS_9

Ion_trans

cNMP_binding

0
200
400
600
800
1000
1083 a.a.

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily H member 3	ELK channel 2

KCNH3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	KCNH3	Q9ULD8	env	Human immunodeficiency virus	P04578	Pull Down	20638388
Cross	KCNH3	Q9ULD8	env	Human immunodeficiency virus	P04578	Anti Tag CoIP	20638388

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 2a	DFNA2A Autosomal Dominant Nonsyndromic Deafness 2a Autosomal Dominant Deafness 2a Deafness, Autosomal Dominant, 2a Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 2a Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 2a Deafness, Autosomal Dominant, Type 2a
Chronic Wasting Disease	Wasting Disease, Chronic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122015	ASP2905	Inhibitor	99.67%	Unkown
HY-RS07127	KCNH3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNH3	MGD	MGI:1341723
Macaca mulatta	KCNH3	VGNC	VGNC:73981
Rattus norvegicus	KCNH3	RGD	RGD:71070
Bos taurus	KCNH3	VGNC	VGNC:30445
Felis catus	KCNH3	VGNC	VGNC:67908
Canis familiaris	KCNH3	VGNC	VGNC:49915
Others	KCNH3	NCBI