Med17 - mediator complex subunit 17 Gene

Also Known as 77kDa; Crsp6; Trap80; C330002H14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234959

Summary

Predicted to enable nuclear receptor coactivator activity and Thyroid Hormone Receptor binding activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in female associated reproductive structure; limb mesenchyme; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2022]

Med17 Products (2)

mRNA Protein Name
NM_001364533.1 NP_001351462.1 mediator of RNA polymerase II transcription subunit 17 isoform 2
NM_144933.2 NP_659182.1 mediator of RNA polymerase II transcription subunit 17 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19338389 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
Cellular Component GO Annotation Evidence References Source
part of mediator complex IDA
IDA: Inferred from direct assay
15340084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 17

  • CRSP complex subunit 6

  • cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)

  • thyroid hormone receptor-associated protein complex 80 kDa component

Med17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Med17 Q8VCD5 Rela Mus musculus Q04207
Y2H
19338389
Intra
Med17 Q8VCD5 Rela Mus musculus Q04207
Anti Bait CoIP
19338389
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08288 MED17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Med17 NCBI NCBI:9440