Plxnb1 - plexin B1 Gene

Also Known as mKIAA0407; 2900002G15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 235611

Summary

Enables GTPase activating protein binding activity and semaphorin receptor activity. Involved in several processes, including negative regulation of osteoblast proliferation; nervous system development; and positive regulation of phosphatidylinositol 3-kinase signaling. Acts upstream of or within positive regulation of axonogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB1 (plexin B1). [provided by Alliance of Genome Resources, Apr 2022]

Plxnb1 Products (1)

mRNA	Protein	Name
NM_172775.2	NP_766363.2	plexin-B1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	22019888	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12123608	MGI
enables semaphorin receptor activity	IMP IMP: Inferred from mutant phenotype	19788569	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	23699507	MGI
involved in negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	22019888	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	19788569	MGI
involved in ossification involved in bone maturation	IMP IMP: Inferred from mutant phenotype	22019888	MGI
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19788569	MGI
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	15330859	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19788569	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	19788569	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	19788569	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of semaphorin receptor complex	IMP IMP: Inferred from mutant phenotype	22019888	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
plexin-B1

Plxnb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Plxnb1	Q8CJH3	Arhgef11	Mus musculus	Q68FM7	Anti Tag CoIP	12123608
Intra	Plxnb1	Q8CJH3	Arhgef11	Mus musculus	Q68FM7	Imaging	12123608
Intra	Plxnb1	Q8CJH3	Arhgef12	Mus musculus	Q8R4H2	Anti Tag CoIP	12123608
Intra	Plxnb1	Q8CJH3	Arhgef12	Mus musculus	Q8R4H2	Anti Bait CoIP	12123608

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10752	PLXNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plxnb1	NCBI	NCBI:5364