PLXNB1 - plexin B1 Gene

Also Known as SEP; PLXN5; PLEXIN-B1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5364

About PLXNB1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,403,854-48,430,310 (from NCBI)

This gene has 19 transcripts (splice variants), 276 orthologues and 8 paralogues. Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues.

Summary

Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

PLXNB1 Products (2)

mRNA Protein Name
NM_001130082.3 NP_001123554.1 plexin-B1 precursor
NM_002673.6 NP_002664.2 plexin-B1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12730235 GOA
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
19843518 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
15218527 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
19843518 GOA
involved in regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
19843518 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
15218527 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19843518 GOA
part of semaphorin receptor complex IDA
IDA: Inferred from direct assay
19843518 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB1 Protein Structure

Sema

Sema: Sema domain (36 - 440)

PSI

PSI: Plexin repeat (481 - 528)

TIG

TIG: IPT/TIG domain (1070 - 1158)

TIG

TIG: IPT/TIG domain (1162 - 1248)

TIG

TIG: IPT/TIG domain (1252 - 1374)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1561 - 2102)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2135 a.a.
Protein Preferred Names Protein Names

plexin-B1

  • plexin 5

PLXNB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLXNB1 O43157 MET Homo sapiens P08581
Anti Tag CoIP
12198496
Intra
PLXNB1 O43157 MET Homo sapiens P08581
Anti Bait CoIP
15184888
Intra
PLXNB1 O43157 MET Homo sapiens P08581
Anti Tag CoIP
22404908
Intra
PLXNB1 O43157 RND3 Homo sapiens P61587
Affinity Techniques
14732713
Intra
PLXNB1 O43157 MST1R Homo sapiens Q04912
Anti Bait CoIP
15184888
Intra
PLXNB1 O43157 RND1 Homo sapiens Q92730
CoIP
12730235
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLXNB1 Proteins

Cat. No. Product Name Accession Purity
HY-P700428 Plexin B1 Protein, Human (HEK293, mFc) O43157 (L20-Q535) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10752 PLXNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLXNB1 VGNC VGNC:76187
Felis catus PLXNB1 VGNC VGNC:68918
Bos taurus PLXNB1 VGNC VGNC:33061
Canis familiaris PLXNB1 VGNC VGNC:44722
Mus musculus PLXNB1 MGD MGI:2154238
Rattus norvegicus PLXNB1 RGD RGD:1310564
Others PLXNB1 NCBI