RND3 - Rho family GTPase 3 Gene

Also Known as ARHE; Rho8; RhoE; memB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 390

About RND3

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:150,468,193-150,487,695 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues and 22 paralogues. Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues.

Summary

This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

RND3 Products (2)

mRNA Protein Name
NM_001254738.1 NP_001241667.1 rho-related GTP-binding protein RhoE precursor
NM_005168.5 NP_005159.1 rho-related GTP-binding protein RhoE precursor

RND3 Protein Structure

Ras

Ras: Ras family (25 - 193)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoE

  • protein MemB

RND3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RND3 P61587 PLXNB1 Homo sapiens O43157
ITC
29040270
Intra
RND3 P61587 PLXNB1 Homo sapiens O43157
GMS
29040270
Intra
RND3 P61587 YWHAZ Homo sapiens P63104
ITC
23622247
Intra
RND3 P61587 YWHAZ Homo sapiens P63104
Pull Down
23622247
Intra
RND3 P61587 YWHAZ Homo sapiens P63104
SPR
23622247
Intra
RND3 P61587 YWHAB Homo sapiens P31946
Pull Down
23622247
Intra
RND3 P61587 YWHAB Homo sapiens P31946
Anti Tag CoIP
33961781
Intra
RND3 P61587 PLXNB2 Homo sapiens O15031
ITC
29040270
Intra
RND3 P61587 PLXNB2 Homo sapiens O15031
GMS
29040270
Intra
RND3 P61587 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
RND3 P61587 CPLANE2 Homo sapiens Q9BU20
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Hydrocephalus

  • Hydrocephalus, Nonsyndromic, Autosomal Recessive

  • Hydrocephalus, X-Linked

  • Hydrocephalus Adverse Event

  • Hydrocephaly Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12033 RND3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RND3 VGNC VGNC:45618
Rattus norvegicus RND3 RGD RGD:1359690
Mus musculus RND3 MGD MGI:1921444
Macaca mulatta RND3 VGNC VGNC:76883
Felis catus RND3 VGNC VGNC:68099
Bos taurus RND3 VGNC VGNC:34006
Others RND3 NCBI