Adcyap1r1 - ADCYAP receptor type I Gene

Also Known as PAC1-R; PACAPR1; PACAP-R1; PACAPR1A; PACAP-R1A

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24167

Summary

Enables Adenylate Cyclase binding activity; neuropeptide binding activity; and small GTPase binding activity. Involved in several processes, including activation of Phospholipase C activity; cAMP-mediated signaling; and positive regulation of intracellular signal transduction. Located in several cellular components, including bicellular tight junction; caveola; and rough endoplasmic reticulum. Biomarker of cystitis. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I). [provided by Alliance of Genome Resources, Apr 2022]

Adcyap1r1 Products (6)

mRNA	Protein	Name
NM_001270579.1	NP_001257508.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor
NM_001270580.1	NP_001257509.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform c precursor
NM_001270581.1	NP_001257510.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor
NM_001270582.1	NP_001257511.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor
NM_001270583.1	NP_001257512.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform e precursor
NM_133511.2	NP_598195.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase binding	IDA IDA: Inferred from direct assay	17680996	RGD
enables neuropeptide binding	IDA IDA: Inferred from direct assay	16905223	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	11353814	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	8396727	RGD
involved in development of primary female sexual characteristics	IEP IEP: Inferred from expression pattern	17065411	RGD
involved in multicellular organismal response to stress	IEP IEP: Inferred from expression pattern	19181454	RGD
involved in negative regulation of response to reactive oxygen species	IDA IDA: Inferred from direct assay	16905223	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	16905223	RGD
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	16401644	RGD
involved in positive regulation of inositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8396727	RGD
involved in positive regulation of small GTPase mediated signal transduction	IMP IMP: Inferred from mutant phenotype	18541665	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15976009	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16820708	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18592413	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	16626868	RGD
located in caveola	IDA IDA: Inferred from direct assay	17680996	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15968088	RGD
located in endosome	IDA IDA: Inferred from direct assay	19416476	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pituitary adenylate cyclase-activating polypeptide type I receptor	ADCYAP receptor type 1 PACAP type I receptor PACAP type IA receptor PACAP-R-1 PACAP-R-1A adenylate cyclase activating polypeptide 1 (pituitary) receptor type I adenylate cyclase activating polypeptide 1 receptor 1 adenylate cyclase activating polyp

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00337	ADCYAP1R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18214	Adcyap1r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24691	Adcyap1r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992108	Efadirelaxin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcyap1r1	NCBI	NCBI:117