ADCYAP1R1 - ADCYAP receptor type I Gene

Also Known as PAC1; PAC1R; PACAPR; PACAPRI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117

About ADCYAP1R1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:31,052,308-31,111,474 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues and 42 paralogues. Biased expression in brain (RPKM 39.8), adrenal (RPKM 5.5) and 1 other tissue.

Summary

This gene encodes type I Adenylate Cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/Secretin Receptor family. This receptor mediates diverse biological actions of Adenylate Cyclase activating polypeptide 1 and is positively coupled to Adenylate Cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

ADCYAP1R1 Products (4)

mRNA	Protein	Name
NM_001118.5	NP_001109.2	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor
NM_001199635.2	NP_001186564.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor
NM_001199636.2	NP_001186565.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor
NM_001199637.2	NP_001186566.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17470806	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCYAP1R1 Protein Structure

HRM

7tm_2

0
100
200
300
400
468 a.a.

Protein Preferred Names	Protein Names
pituitary adenylate cyclase-activating polypeptide type I receptor	PACAP receptor 1

Recombinant ADCYAP1R1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77120	ADCYAP1R1 Protein, Human (HEK293, Fc, solution)	P41586 (D24-A155)	≥ 85%, as determined by reducing SDS-PAGE.

ADCYAP1R1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89687	PACAP Receptor Antibody (YA9031)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Accommodative Spasm	Spasm Of Accommodation Cyclospasm Ciliary Muscle Spasm Ciliary Body Spasm
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Chondrodysplasia, Blomstrand Type	Chondrodysplasia Blomstrand Type BOCD Blomstrand Lethal Chondrodysplasia Blomstrand Lethal Osteochondrodysplasia Blomstrand'S Lethal Chondrodysplasia Blc Blomstrand Chondrodysplasia Blomstrand Osteochondrodysplasia
Isolated Growth Hormone Deficiency, Type Ib	Isolated Growth Hormone Deficiency Type Ib IGHD1B Ighd Ib Growth Hormone Deficiency, Isolated, Type Ib Congenital Ighd Type Ib Congenital Isolated Gh Deficiency Type Ib Congenital Isolated Growth Hormone Deficiency Type Ib Dwarfism Of Sindh Pituitary Dwarfism I Isolated Growth Hormone Deficiency Type 1b Ighd 1b Growth Hormone Deficiency, Isolated, 1b
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Photokeratitis
Acute Endometritis
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00337	ADCYAP1R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18214	Adcyap1r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24691	Adcyap1r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992108	Efadirelaxin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADCYAP1R1	MGD	MGI:108449
Rattus norvegicus	ADCYAP1R1	RGD	RGD:2038
Felis catus	ADCYAP1R1	VGNC	VGNC:59623
Macaca mulatta	ADCYAP1R1	VGNC	VGNC:69526
Bos taurus	ADCYAP1R1	VGNC	VGNC:25652
Canis familiaris	ADCYAP1R1	VGNC	VGNC:37627
Others	ADCYAP1R1	NCBI