Plxna4 - plexin A4 Gene

Mus musculus

Also known as Plxa4; mKIAA1550; 9330117B14

Gene ID: 243743 | Gene type: protein coding

About Plxna4

Summary

Enables semaphorin receptor activity. Involved in axon guidance; cranial nerve structural organization; and embryonic heart tube development. Acts upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Apr 2022]

Plxna4 Products(1)

mRNA	Protein	Name
NM_175750.3	NP_786926.2	plexin-A4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15814794	MGI
enables semaphorin receptor activity	IGI IGI: Inferred from genetic interaction	12591607	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within chemorepulsion of branchiomotor axon	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within cranial nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in embryonic heart tube development	IGI IGI: Inferred from genetic interaction	30735130	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	30735130	MGI
acts upstream of or within facial nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within glossopharyngeal nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in maintenance of synapse structure	IDA IDA: Inferred from direct assay	24831527	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	24831527	MGI
involved in motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within nervous system development	IGI IGI: Inferred from genetic interaction	12591607	MGI
acts upstream of or within neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within postganglionic parasympathetic fiber development	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within regulation of negative chemotaxis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	12591607	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in sympathetic neuron axon guidance	IGI IGI: Inferred from genetic interaction	30735130	MGI
acts upstream of or within trigeminal nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in trigeminal nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within vagus nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	24831527	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	24831527	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plexin-A4

Plxna4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Plxna4	Q80UG2	Sema6a	Mus musculus	O35464	Anti Bait CoIP	20606624
Intra	Plxna4	Q80UG2	Sema6a	Mus musculus	O35464	IF	20606624
Intra	Plxna4	Q80UG2	Sema6a	Mus musculus	O35464	Anti Tag CoIP	20606624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10751	PLXNA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plxna4	NCBI	NCBI:91584

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