Rab3a - RAB3A, member RAS oncogene family Gene

Rattus norvegicus

Also known as RAB3

Gene ID: 25531 | Gene type: protein coding

About Rab3a

Summary

Enables several functions, including ATPase binding activity; GTP binding activity; and protein C-terminus binding activity. Involved in regulation of secretion by cell; regulation of synaptic vesicle priming; and synaptic vesicle cycle. Located in several cellular components, including cytosol; secretory vesicle; and terminal bouton. Part of protein-containing complex. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB3A (RAB3A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab3a Products(1)

mRNA	Protein	Name
NM_013018.2	NP_037150.2	ras-related protein Rab-3A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	11062069	RGD
enables ATPase binding	IPI IPI: Inferred from physical interaction	11062069	RGD
enables GDP-dissociation inhibitor binding	IPI IPI: Inferred from physical interaction	12426384	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	8807639	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7532276	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of dopamine secretion	IDA IDA: Inferred from direct assay	28370453	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	28057568	RGD
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	21689256	RGD
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	16141272	RGD
involved in synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	16141272	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16141272	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12426384	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	17311845	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	8043272	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17110340	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	16141272	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-3A

Ras-related small GTP binding protein 3A

Rab3a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rab3a	P63012	Rph3a	Rattus norvegicus	P47709	Anti Bait CoIP	16763567
Intra	Rab3a	P63012	Rph3a	Rattus norvegicus	P47709	X-Ray Diffraction	10025402

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11555	RAB3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab3a	NCBI	NCBI:5864

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