Rph3a - rabphilin 3A Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171039

Summary

Enables several functions, including anion binding activity; calcium-dependent phospholipid binding activity; and metal ion binding activity. Involved in brain development; dendritic spine organization; and regulation of NMDA Receptor activity. Located in several cellular components, including dendritic spine; postsynaptic membrane; and secretory vesicle. Is extrinsic component of membrane. Part of protein-containing complex. Is active in cholinergic synapse and neuromuscular junction. Is extrinsic component of synaptic vesicle membrane. Colocalizes with Golgi apparatus. Orthologous to human RPH3A (rabphilin 3A). [provided by Alliance of Genome Resources, Apr 2022]

Rph3a Products (1)

mRNA	Protein	Name
NM_133518.2	NP_598202.2	rabphilin-3A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	17166855	RGD
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	17166855	RGD
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	18945677	RGD
enables phosphate ion binding	IDA IDA: Inferred from direct assay	11640918	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	18945677	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7802677	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14960300	RGD
enables selenium binding	IDA IDA: Inferred from direct assay	10025402	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	10025402	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in dendritic spine organization	IMP IMP: Inferred from mutant phenotype	26679993	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	26679993	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	8060298	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	26679993	RGD
located in extrinsic component of membrane	IDA IDA: Inferred from direct assay	7946335	RGD
is active in extrinsic component of synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in extrinsic component of synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8060298	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	8060298	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	26679993	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	14960300	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	18573236	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	8617225	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	7946335	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
rabphilin-3A	exophilin-1 rabphilin 3A homolog

Rph3a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rph3a	P47709	Snap25	Rattus norvegicus	P60881	Pull Down	16763567

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12157	RPH3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rph3a	NCBI	NCBI:22895