2. Gene
  3. EGFL6 - EGF like domain multiple 6 Gene

EGFL6 - EGF like domain multiple 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as W80; MAEG

Gene ID: 25975 | Gene type: protein coding

About EGFL6

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:13,569,601-13,633,575 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 1 paralogue. Restricted expression toward placenta (RPKM 287.0).

Summary

This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp Integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

EGFL6 Products(2)

mRNA Protein Name
NM_001167890.2 NP_001161362.1 epidermal growth factor-like protein 6 isoform 2 precursor
NM_015507.4 NP_056322.2 epidermal growth factor-like protein 6 isoform 1 precursor

EGFL6 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (94 - 125)

EGF_CA

EGF_CA: Calcium-binding EGF domain (174 - 207)

EGF_CA

EGF_CA: Calcium-binding EGF domain (219 - 255)

MAM

MAM: MAM domain, meprin/A5/mu (402 - 545)

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  • 553 a.a.
Protein Preferred Names Protein Names

epidermal growth factor-like protein 6

EGF repeat-containing protein 6

Recombinant EGFL6 Proteins

Cat. No. Product Name Accession Purity
HY-P76899 EGF-L6 Protein, Human (sf9, His-Flag) Q8IUX8 (N22-D553) ≥95%
HY-P76900 EGF-L6 Protein, Human (sf9, His) Q8IUX8 (M1-D553) ≥95%

Related Diseases

Diseases Alias
Fibrous Meningioma

Fibroblastic Meningioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04205 EGFL6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EGFL6 VGNC VGNC:61756
Macaca mulatta EGFL6 VGNC VGNC:72172
Bos taurus EGFL6 VGNC VGNC:56707
Rattus norvegicus EGFL6 RGD RGD:1563321
Mus musculus EGFL6 MGD MGI:1858599
Canis familiaris EGFL6 VGNC VGNC:40236
Others EGFL6 NCBI