GGT1 - gamma-glutamyltransferase 1 Gene
Also Known as GGT; GTG; GGTD; CD224; GGT 1; D22S672; D22S732
Species: Homo sapiens
About GGT1
This gene has 26 transcripts (splice variants), 296 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 54.5), duodenum (RPKM 22.2) and 11 other tissues.
Summary
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of Amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and Other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
GGT1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001288833.2 | NP_001275762.1 | glutathione hydrolase 1 proenzyme precursor |
| NM_013421.3 | NP_038265.2 | glutathione hydrolase 1 proenzyme precursor |
| NM_013430.3 | NP_038347.2 | glutathione hydrolase 1 proenzyme precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables glutathione hydrolase activity |
IDA
IDA: Inferred from direct assay
|
20622017 | GOA |
| enables leukotriene-C(4) hydrolase |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| enables leukotriene-C(4) hydrolase |
IMP
IMP: Inferred from mutant phenotype
|
14754911 | GOA |
| enables peptidyltransferase activity |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15528406 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in amino acid metabolic process |
IDA
IDA: Inferred from direct assay
|
14754911 | GOA |
| involved in fatty acid metabolic process |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| involved in glutamate metabolic process |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| involved in glutathione catabolic process |
IDA
IDA: Inferred from direct assay
|
17924658 | GOA |
| involved in leukotriene D4 biosynthetic process |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| involved in leukotriene D4 biosynthetic process |
IMP
IMP: Inferred from mutant phenotype
|
14754911 | GOA |
| involved in leukotriene metabolic process |
IDA
IDA: Inferred from direct assay
|
21447318 | GOA |
| involved in proteolysis |
IMP
IMP: Inferred from mutant phenotype
|
14754911 | GOA |
| involved in zymogen activation |
IDA
IDA: Inferred from direct assay
|
23682772 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
23682772 | GOA |
GGT1 Protein Structure
G_glu_transpept: Gamma-glutamyltranspeptidase (56 - 564)
- 0
- 100
- 200
- 300
- 400
- 500
- 569 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glutathione hydrolase 1 proenzyme |
|
GGT1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GGT1 | P19440 | GGT2P | Homo sapiens | P36268 | 33961781 |
Recombinant GGT1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P700729 | GGT1 Protein, Human (HEK293, His) | P19440-1 (P27-Y569) | ≥ 95%, as determined by reducing SDS-PAGE. |
GGT1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82889 | GGT1 Antibody (YA2634) | WB, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Glutathionuria |
|
|
| Extrahepatic Cholestasis |
|
|
| Liver Disease |
|
|
| Biliary Atresia |
|
|
| Obstructive Jaundice |
|
|
| Liver Cirrhosis |
|
|
| Vertebrobasilar Insufficiency |
|
|
| Pleuropneumonia |
|
|
| Intrahepatic Cholestasis |
|
|
| Alcohol Use Disorder |
|
|
| Viral Hepatitis |
|
|
| Biliary Atresia, Extrahepatic |
|
|
| Hepatitis C |
|
|
| Hemochromatosis, Neonatal |
|
|
| Cholestasis |
|
|
| Hepatitis |
|
|
| Alcoholic Hepatitis |
|
|
| Inferolateral Myocardial Infarct |
|
|
| Hepatitis B |
|
|
| Alcohol Dependence |
|
|
| Alkaline Phosphatase, Plasma Level Of, Quantitative Trait Locus 1 |
|
|
| Cholestasis, Progressive Familial Intrahepatic, 1 |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Acne |
|
|
| Opisthorchiasis |
|
|
| Glutathione Synthetase Deficiency |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Hyperuricemia |
|
|
| Hepatic Tuberculosis |
|
|
| Choledocholithiasis |
|
|
| Cholangitis |
|
|
| Fascioliasis |
|
|
| Renal Artery Obstruction |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Pancreatitis |
|
|
| Primary Biliary Cholangitis |
|
|
| Autoimmune Hepatitis |
|
|
| Tobacco Addiction |
|
|
| Alcoholic Liver Cirrhosis |
|
|
| Hypertension, Diastolic |
|
|
| Osteogenesis Imperfecta, Type Iv |
|
|
| Portal Hypertension |
|
|
| Pancreatic Cancer |
|
|
| Porphyria Cutanea Tarda |
|
|
| Hutchinson-Gilford Progeria Syndrome |
|
|
| Typhoid Fever |
|
|
| Diabetes Mellitus |
|
|
| Cholangiocarcinoma |
|
|
| Lipid Metabolism Disorder |
|
|
| Cardiovascular System Disease |
|
|
| Monocarboxylate Transporter 1 Deficiency |
|
|
| Hepatocellular Carcinoma |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Strabismus |
|
|
| Constipation |
|
|
| Thrombocytopenia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | GGT1 | RGD | RGD:2683 |
| Mus musculus | GGT1 | MGD | MGI:95706 |