Clnk - cytokine-dependent hematopoietic cell linker Gene

Also Known as MIST

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27278

Summary

Involved in several processes, including mast cell degranulation; negative regulation of natural killer cell activation; and positive regulation of natural killer cell cytokine production. Acts upstream of or within transmembrane receptor protein tyrosine kinase signaling pathway. Located in mast cell granule. Part of protein-containing complex. Orthologous to human CLNK (cytokine dependent hematopoietic cell linker). [provided by Alliance of Genome Resources, Apr 2022]

Clnk Products (1)

mRNA	Protein	Name
NM_013748.3	NP_038776.3	cytokine-dependent hematopoietic cell linker

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10562326	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12681493	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	10562326	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: Inferred from mutant phenotype	10744659	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	26009488	MGI
involved in mast cell degranulation	IMP IMP: Inferred from mutant phenotype	10744659	MGI
involved in negative regulation of natural killer cell activation	IMP IMP: Inferred from mutant phenotype	15199160	MGI
involved in positive regulation of natural killer cell cytokine production	IMP IMP: Inferred from mutant phenotype	16439675	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in mast cell granule	IDA IDA: Inferred from direct assay	10744659	MGI
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	12681493	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytokine-dependent hematopoietic cell linker	mast cell immunoreceptor signal transducer

Clnk Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Clnk	Q9QZE2	Fgr	Mus musculus	P14234	Anti Bait CoIP	16439675
Intra	Clnk	Q9QZE2	Fgr	Mus musculus	P14234	Anti Tag CoIP	16439675

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02826	CLNK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clnk	NCBI	NCBI:116449