CLNK - cytokine dependent hematopoietic cell linker Gene

Also Known as MIST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116449

About CLNK

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:10,486,395-10,734,846 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.1), lymph node (RPKM 0.5) and 12 other tissues.

Summary

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

CLNK Products (1)

mRNA Protein Name
NM_052964.4 NP_443196.2 cytokine-dependent hematopoietic cell linker

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
26009488 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLNK Protein Structure

SH2

SH2: SH2 domain (309 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

cytokine-dependent hematopoietic cell linker

  • mast cell immunoreceptor signal transducer

CLNK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLNK Q7Z7G1 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
CLNK Q7Z7G1 ERBB2 Homo sapiens P04626
Protein Array
16273093
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 6

  • Habc

  • Hypomyelinating Leukodystrophy 6

  • HLD6

  • H-Abc

  • Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

  • Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

  • Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

  • HLD

  • Leukodystrophy, Hypomyelinating, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02826 CLNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLNK VGNC VGNC:27454
Macaca mulatta CLNK VGNC VGNC:71196
Rattus norvegicus CLNK RGD RGD:1562417
Felis catus CLNK VGNC VGNC:60969
Mus musculus CLNK MGD MGI:1351468
Canis familiaris CLNK VGNC VGNC:39352
Others CLNK NCBI