2. Gene
  3. NUDT2 - nudix hydrolase 2 Gene

NUDT2 - nudix hydrolase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APAH1; IDDPN

Gene ID: 318 | Gene type: protein coding

About NUDT2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,329,569-34,343,699 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 11.6), prostate (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The Enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

NUDT2 Products(4)

mRNA Protein Name
NM_001161.5 NP_001152.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_001244390.2 NP_001231319.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_147172.3 NP_671701.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_147173.3 NP_671702.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

NUDT2 Protein Structure

NUDIX

NUDIX: NUDIX domain (14 - 132)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Ap4A hydrolase 1

Recombinant NUDT2 Proteins

Cat. No. Product Name Accession Purity
HY-P77108 NUDT2 Protein, Human (His) P50583 (M1-A147) ≥95%

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Or Without Peripheral Neuropathy

IDDPN
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09668 NUDT2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUDT2 VGNC VGNC:68590
Rattus norvegicus NUDT2 RGD RGD:1303023
Bos taurus NUDT2 VGNC VGNC:32335
Mus musculus NUDT2 MGD MGI:1913651
Canis familiaris NUDT2 VGNC VGNC:44033
Others NUDT2 NCBI