Tns3 - tensin 3 Gene

Also Known as TEM6; Tens1; F830010I22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 319939

Summary

Acts upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Predicted to be located in cytosol and focal adhesion. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Apr 2022]

Tns3 Products (1)

mRNA	Protein	Name
NM_001083587.1	NP_001077056.1	tensin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor adaptor activity	IDA IDA: Inferred from direct assay	27505886	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27505886	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone resorption	IMP IMP: Inferred from mutant phenotype	27505886	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15733665	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15733665	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	15733665	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	27505886	MGI
acts upstream of or within podosome assembly	IMP IMP: Inferred from mutant phenotype	27505886	MGI
acts upstream of or within positive regulation of Rac protein signal transduction	IPI IPI: Inferred from physical interaction	27505886	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15733665	MGI
involved in positive regulation of guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	27505886	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in podosome	IDA IDA: Inferred from direct assay	27505886	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tensin-3	tensin-like SH2 domain containing 1 tensin-like SH2 domain-containing protein 1 tumor endothelial marker 6

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14869	TNS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tns3	NCBI	NCBI:64759