HSD17B2 - hydroxysteroid 17-beta dehydrogenase 2 Gene

Also Known as HSD17; SDR9C2; EDH17B2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3294

About HSD17B2

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:82,035,253-82,098,534 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 25 paralogues. Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues.

Summary

Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

HSD17B2 Products (1)

mRNA Protein Name
NM_002153.3 NP_002144.1 17-beta-hydroxysteroid dehydrogenase type 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
8099587 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables testosterone dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
8099587 GOA
Biological Process GO Annotation Evidence References Source
involved in androgen metabolic process IDA
IDA: Inferred from direct assay
11940569 GOA
involved in estrogen biosynthetic process IDA
IDA: Inferred from direct assay
11940569 GOA
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
17538076 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10385431 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B2 Protein Structure

adh_short

adh_short: short chain dehydrogenase (83 - 250)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase type 2

  • 17-beta-HSD 2

HSD17B2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSD17B2 P37059 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
33961781
Intra
HSD17B2 P37059 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Progesterone Resistance

  • Pseudocorpus Luteum Insufficiency
Endometriosis Of Ovary

  • Ovarian Endometriosis
Asperger Syndrome

  • Asperger Disorder

  • Asperger Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06395 HSD17B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HSD17B2 VGNC VGNC:41805
Macaca mulatta HSD17B2 VGNC VGNC:99512
Bos taurus HSD17B2 VGNC VGNC:29973
Mus musculus HSD17B2 MGD MGI:1096386
Felis catus HSD17B2 VGNC VGNC:67657
Rattus norvegicus HSD17B2 RGD RGD:621803
Others HSD17B2 NCBI