SH3RF3 - SH3 domain containing ring finger 3 Gene

Also Known as POSH2; SH3MD4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 344558

About SH3RF3

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:109,129,205-109,504,634 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Involved in positive regulation of JNK cascade and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF3 Products (1)

mRNA Protein Name
NM_001099289.3 NP_001092759.1 E3 ubiquitin-protein ligase SH3RF3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16374509 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
20696164 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
20696164 GOA
involved in protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
20696164 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3RF3 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (57 - 97)

SH3_9

SH3_9: Variant SH3 domain (201 - 249)

SH3_9

SH3_9: Variant SH3 domain (263 - 315)

SH3_9

SH3_9: Variant SH3 domain (471 - 521)

SH3_9

SH3_9: Variant SH3 domain (831 - 880)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 882 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF3

  • SH3 domain-containing RING finger protein 3

SH3RF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3RF3 Q8TEJ3 PAK2 Homo sapiens Q13177
Phage Display
16374509
Intra
SH3RF3 Q8TEJ3 PAK2 Homo sapiens Q13177
Filter Binding
16374509
Intra
SH3RF3 Q8TEJ3 RAC1 Homo sapiens P63000
Solid Phase Assay
20696164
Intra
SH3RF3 Q8TEJ3 RAC1 Homo sapiens P63000
Anti Tag CoIP
20696164
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 17

  • RP17

  • Retinitis Pigmentosa-17

  • Retinitis Pigmentosa, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12846 SH3RF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SH3RF3 VGNC VGNC:46134
Macaca mulatta SH3RF3 VGNC VGNC:77302
Felis catus SH3RF3 VGNC VGNC:65115
Rattus norvegicus SH3RF3 RGD RGD:1589772
Bos taurus SH3RF3 VGNC VGNC:34581
Mus musculus SH3RF3 MGD MGI:2444637
Others SH3RF3 NCBI