Pla2g6 - phospholipase A2 group VI Gene

Also Known as iPla2; PNPLA9; GVI PLA2; caI-PLA2; iPLA2-beta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360426

Summary

Enables several functions, including ATP-dependent protein binding activity; calcium-independent Phospholipase A2 activity; and palmitoyl-CoA hydrolase activity. Involved in several processes, including cardiolipin acyl-chain remodeling; positive regulation of nitrogen compound metabolic process; and positive regulation of secretion. Located in cytosol and mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (Phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g6 Products (2)

mRNA Protein Name
NM_001005560.1 NP_001005560.1 85/88 kDa calcium-independent phospholipase A2 isoform 1
NM_001270796.1 NP_001257725.1 85/88 kDa calcium-independent phospholipase A2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent protein binding IDA
IDA: Inferred from direct assay
20732873 RGD
enables calcium-independent phospholipase A2 activity IDA
IDA: Inferred from direct assay
9111008 RGD
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
18937505 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15576376 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiolipin acyl-chain remodeling IDA
IDA: Inferred from direct assay
24648512 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
16436530 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
15830227 RGD
involved in negative regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15132431 RGD
involved in positive regulation of arachidonate secretion IDA
IDA: Inferred from direct assay
15576376 RGD
involved in positive regulation of arachidonate secretion IMP
IMP: Inferred from mutant phenotype
20732873 RGD
involved in positive regulation of ceramide biosynthetic process IDA
IDA: Inferred from direct assay
18936091 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
21178110 RGD
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
12023524 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
11278673 RGD
involved in positive regulation of protein kinase C signaling IMP
IMP: Inferred from mutant phenotype
22057271 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15576376 RGD
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
18936091 RGD
involved in regulation of store-operated calcium channel activity IMP
IMP: Inferred from mutant phenotype
12547829 RGD
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
20732873 RGD
involved in urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
12750876 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
12183647 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

85/88 kDa calcium-independent phospholipase A2

  • 2-lysophosphatidylcholine acylhydrolase

  • 85 kDa calcium-independent phospholipase A2

  • intracellular membrane-associated calcium-independent phospholipase A2 beta

  • palmitoyl-CoA hydrolase

  • patatin-like phospholipase domain-containing protein 9

  • phospholipa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18705 Azoramide 99.57% Unkown
HY-122949 Momordicine I 97.0% Unkown
HY-RS10633 PLA2G6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g6 NCBI NCBI:8398