Pla2g6 - phospholipase A2 group VI Gene

Rattus norvegicus

Also known as iPla2; PNPLA9; GVI PLA2; caI-PLA2; iPLA2-beta

Gene ID: 360426 | Gene type: protein coding

About Pla2g6

Summary

Enables several functions, including ATP-dependent protein binding activity; calcium-independent Phospholipase A2 activity; and palmitoyl-CoA hydrolase activity. Involved in several processes, including cardiolipin acyl-chain remodeling; positive regulation of nitrogen compound metabolic process; and positive regulation of secretion. Located in cytosol and mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (Phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g6 Products(2)

mRNA	Protein	Name
NM_001005560.1	NP_001005560.1	85/88 kDa calcium-independent phospholipase A2 isoform 1
NM_001270796.1	NP_001257725.1	85/88 kDa calcium-independent phospholipase A2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent protein binding	IDA IDA: Inferred from direct assay	20732873	RGD
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	9111008	RGD
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	18937505	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15576376	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiolipin acyl-chain remodeling	IDA IDA: Inferred from direct assay	24648512	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	16436530	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15830227	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	15132431	RGD
involved in positive regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	15576376	RGD
involved in positive regulation of arachidonate secretion	IMP IMP: Inferred from mutant phenotype	20732873	RGD
involved in positive regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	18936091	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	21178110	RGD
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	12023524	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	11278673	RGD
involved in positive regulation of protein kinase C signaling	IMP IMP: Inferred from mutant phenotype	22057271	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15576376	RGD
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	18936091	RGD
involved in regulation of store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	12547829	RGD
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	20732873	RGD
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	12750876	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	12183647	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

85/88 kDa calcium-independent phospholipase A2

2-lysophosphatidylcholine acylhydrolase	85 kDa calcium-independent phospholipase A2
intracellular membrane-associated calcium-independent phospholipase A2 beta	palmitoyl-CoA hydrolase
patatin-like phospholipase domain-containing protein 9	phospholipa

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18705	Azoramide		99.57%	Unkown
HY-122949	Momordicine I		97.0%	Unkown
HY-RS10633	PLA2G6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g6	NCBI	NCBI:8398

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