Scrib - scribble planar cell polarity protein Gene

Rattus norvegicus

Also known as RGD1565055

Gene ID: 362938 | Gene type: protein coding

About Scrib

Summary

Involved in several processes, including astrocyte cell migration; protein localization to postsynapse; and regulation of postsynaptic neurotransmitter receptor internalization. Located in cell-cell junction; cytoplasm; and postsynaptic density. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Scrib Products(1)

mRNA	Protein	Name
NM_001191879.3	NP_001178808.1	protein scribble homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17081755	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte cell migration	IMP IMP: Inferred from mutant phenotype	17081755	RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	25310985	RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	25310985	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	25310985	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	25310985	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	25310985	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	25310985	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	17081755	RGD
is active in extrinsic component of postsynaptic density membrane	IDA IDA: Inferred from direct assay	25310985	RGD
is active in extrinsic component of postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	25310985	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25310985	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25310985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein scribble homolog

scribbled homolog

scribbled planar cell polarity protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175276	JNK-IN-24	Inhibitor	/	Unkown
HY-RS12562	SCRIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scrib	NCBI	NCBI:23513

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