Prdm14 - PR domain containing 14 Gene

Mus musculus

Gene ID: 383491 | Gene type: protein coding

About Prdm14

Summary

Enables RNA binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in germ cell development; positive regulation of flagellated sperm motility; and positive regulation of stem cell population maintenance. Acts upstream of or within several processes, including histone H3-R26 methylation; inner cell mass cell fate commitment; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human PRDM14 (PR/SET domain 14). [provided by Alliance of Genome Resources, Apr 2022]

Prdm14 Products(1)

mRNA	Protein	Name
NM_001081209.2	NP_001074678.2	PR domain zinc finger protein 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	24268575	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	21183938	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	24268575	MGI
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	24183668	MGI
enables methyltransferase regulator activity	IDA IDA: Inferred from direct assay	24183668	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26523946	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	18622394	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18622394	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	24268575	MGI
acts upstream of or within epigenetic regulation of gene expression	IGI IGI: Inferred from genetic interaction	22482507	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	18622394	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23670199	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	18622394	MGI
involved in germ cell development	IMP IMP: Inferred from mutant phenotype	26523391	MGI
acts upstream of or within germ-line stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	23670199	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	18622394	MGI
acts upstream of or within inactivation of paternal X chromosome by genomic imprinting	IMP IMP: Inferred from mutant phenotype	24268575	MGI
acts upstream of or within inner cell mass cell fate commitment	IDA IDA: Inferred from direct assay	24183668	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23670199	MGI
acts upstream of or within negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	23670199	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24268575	MGI
involved in positive regulation of flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	27281218	MGI
involved in positive regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	26523391	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18622394	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24268575	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24183668	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

PR domain zinc finger protein 14

PR domain-containing protein 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11064	PRDM14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prdm14	NCBI	NCBI:63978

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