Prdm14 - PR domain containing 14 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 383491

Summary

Enables RNA binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in germ cell development; positive regulation of flagellated sperm motility; and positive regulation of stem cell population maintenance. Acts upstream of or within several processes, including histone H3-R26 methylation; inner cell mass cell fate commitment; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human PRDM14 (PR/SET domain 14). [provided by Alliance of Genome Resources, Apr 2022]

Prdm14 Products (1)

mRNA Protein Name
NM_001081209.2 NP_001074678.2 PR domain zinc finger protein 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
24268575 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
21183938 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
24268575 MGI
enables histone methyltransferase binding IPI
IPI: Inferred from physical interaction
24183668 MGI
enables methyltransferase regulator activity IDA
IDA: Inferred from direct assay
24183668 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26523946 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell fate specification IMP
IMP: Inferred from mutant phenotype
18622394 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18622394 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
24268575 MGI
acts upstream of or within epigenetic regulation of gene expression IGI
IGI: Inferred from genetic interaction
22482507 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
18622394 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23670199 MGI
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
18622394 MGI
involved in germ cell development IMP
IMP: Inferred from mutant phenotype
26523391 MGI
acts upstream of or within germ-line stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
23670199 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
18622394 MGI
acts upstream of or within inactivation of paternal X chromosome by genomic imprinting IMP
IMP: Inferred from mutant phenotype
24268575 MGI
acts upstream of or within inner cell mass cell fate commitment IDA
IDA: Inferred from direct assay
24183668 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23670199 MGI
acts upstream of or within negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
23670199 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24268575 MGI
involved in positive regulation of flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
27281218 MGI
involved in positive regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
26523391 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18622394 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
24268575 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24183668 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PR domain zinc finger protein 14

  • PR domain-containing protein 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11064 PRDM14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13689G Go 6983 (GMP) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdm14 NCBI NCBI:63978