2. Gene
  3. Mir154 - microRNA 154 Gene

Mir154 - microRNA 154 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn154; mir-154; mmu-mir-154

Gene ID: 387172 | Gene type: ncRNA

About Mir154

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular metabolic process IMP
IMP: Inferred from mutant phenotype
25124681 MGI
acts upstream of or within cellular response to ethanol IEP
IEP: Inferred from expression pattern
19091803 MGI
acts upstream of or within cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within cellular response to phenylalanine IEP
IEP: Inferred from expression pattern
26822703 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
25124681 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within negative regulation of mesenchymal stem cell differentiation IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within negative regulation of mesenchymal stem cell differentiation IMP
IMP: Inferred from mutant phenotype
25959411 MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
25959411 MGI
acts upstream of or within regulation of miRNA-mediated gene silencing IMP
IMP: Inferred from mutant phenotype
25959411 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00313 hsa-miR-154-3p mimic 96.76% Unkown
HY-R00314 hsa-miR-154-5p mimic 96.16% Unkown
HY-R00313A hsa-miR-154-3p agomir / Unkown
HY-R00314A hsa-miR-154-5p agomir / Unkown
HY-RI00313 hsa-miR-154-3p inhibitor / Unkown
HY-RI00313A hsa-miR-154-3p antagomir / Unkown
HY-RI00314 hsa-miR-154-5p inhibitor / Unkown
HY-RI00314A hsa-miR-154-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir154 NCBI NCBI:406946