2. Gene
  3. Mir122 - microRNA 122 Gene

Mir122 - microRNA 122 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mir122a; Mir122b; mir-122; Mirn122a; Mirn122b; mmu-mir-122

Gene ID: 387231 | Gene type: ncRNA

About Mir122

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
19520079 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within erythrocyte differentiation IGI
IGI: Inferred from genetic interaction
21364282 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: Inferred from genetic interaction
21364282 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
21364282 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
23185045 MGI
part of RNAi effector complex IDA
IDA: Inferred from direct assay
30971389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-132598A Miravirsen sodium 99.44% Phase 2
HY-132598 Miravirsen Inhibitor 97.37% Phase 2
Pre-clinical Phase
Bioactive Molecules (36)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2468 Xylobiose 98.0% Unkown
HY-R00116 hsa-miR-122-5p mimic 97.63% Unkown
HY-RI00116 hsa-miR-122-5p inhibitor 99.60% Unkown
HY-R00116A hsa-miR-122-5p agomir 97.97% Unkown
HY-132600 RG-101 / Unkown
HY-132600A RG-101 sodium Inhibitor 95.38% Unkown
HY-R00112 hsa-miR-122-3p mimic 97.14% Unkown
HY-R00125 hsa-miR-122b-3p mimic 95.35% Unkown
HY-RI00112 hsa-miR-122-3p inhibitor 93.49% Unkown
HY-RI00116A hsa-miR-122-5p antagomir 98.98% Unkown
HY-RI00125 hsa-miR-122b-3p inhibitor 92.79% Unkown
HY-RI00125A hsa-miR-122b-3p antagomir 93.82% Unkown
HY-R00112A hsa-miR-122-3p agomir / Unkown
HY-R00125A hsa-miR-122b-3p agomir / Unkown
HY-R00126 hsa-miR-122b-5p mimic / Unkown
HY-R00126A hsa-miR-122b-5p agomir / Unkown
HY-R02635 mmu-miR-122-3p mimic / Unkown
HY-R02635A mmu-miR-122-3p agomir / Unkown
HY-R02638 mmu-miR-122b-5p mimic / Unkown
HY-R02638A mmu-miR-122b-5p agomir / Unkown
HY-R04218 rno-miR-122-3p mimic / Unkown
HY-R04218A rno-miR-122-3p agomir / Unkown
HY-R04219 rno-miR-122b mimic / Unkown
HY-R04219A rno-miR-122b agomir / Unkown
HY-RI00112A hsa-miR-122-3p antagomir / Unkown
HY-RI00126 hsa-miR-122b-5p inhibitor / Unkown
HY-RI00126A hsa-miR-122b-5p antagomir / Unkown
HY-RI02635 mmu-miR-122-3p inhibitor / Unkown
HY-RI02635A mmu-miR-122-3p antagomir / Unkown
HY-RI02638 mmu-miR-122b-5p inhibitor / Unkown
HY-RI02638A mmu-miR-122b-5p antagomir / Unkown
HY-RI04218 rno-miR-122-3p inhibitor / Unkown
HY-RI04218A rno-miR-122-3p antagomir / Unkown
HY-RI04219 rno-miR-122b inhibitor / Unkown
HY-RI04219A rno-miR-122b antagomir / Unkown
HY-R04632 rno-miR-122-5p agomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir122 NCBI NCBI:406906