KDM4E - lysine demethylase 4E Gene

Also Known as KDM5E; JMJD2E; KDM4DL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 390245

About KDM4E

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:95,025,258-95,027,596 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 10 paralogues.

Summary

The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral Infection or carcinogenesis, so inhibitors of these Enzymes are desired. [provided by RefSeq, Dec 2016]

KDM4E Products (1)

mRNA Protein Name
NM_001161630.1 NP_001155102.1 lysine-specific demethylase 4E

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K9me2/H3K9me3 demethylase activity IDA
IDA: Inferred from direct assay
21914792 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21914792 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4E Protein Structure

JmjN

JmjN: jmjN domain (16 - 50)

JmjC

JmjC: JmjC domain, hydroxylase (176 - 292)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 4E

  • KDM4D-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-RS07217 KDM4E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126207 CBN209350 Inhibitor / Unkown