MIR145 - microRNA 145 Gene
Also Known as MIRN145; miR-145; miRNA145
Species: Homo sapiens
About MIR145
This gene has 1 transcript (splice variant) and 113 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
23076445 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
15131085 | GOA |
| enables mRNA base-pairing translational repressor activity |
IMP
IMP: Inferred from mutant phenotype
|
25704091 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
31926946 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Vascular Disease |
|
|
| Diffuse Large B-Cell Lymphoma |
|
|
| Burkitt Lymphoma |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Prostate Cancer |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Diabetes Mellitus |
|
|
| Lung Cancer |
|
|
| Gastric Cancer |
|
|
| Colorectal Cancer |
|
|
| Endometriosis |
|
|
| Ovarian Serous Carcinoma |
|
|
| Cardiovascular System Disease |
|
|
| Esophagus Adenocarcinoma |
|
|
| Multiple Sclerosis |
|
|
| Testicular Germ Cell Tumor |
|
|
| Oral Squamous Cell Carcinoma |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Bladder Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Common Bile Duct Disease |
|
|
| Male Reproductive Organ Cancer |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Large Intestine Cancer |
|
|
| Male Reproductive System Disease |
|
|
| Esophageal Disease |
|
|
| Reproductive System Disease |
|
|
| Rectal Benign Neoplasm |
|
|
| Bladder Disease |
|
|
| Larynx Cancer |
|
|
| Respiratory System Cancer |
|
|
| Oral Cavity Cancer |
|
|
| Thoracic Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Breast Cancer |
|
|
| Colonic Disease |
|
|
| Stomach Disease |
|
|
| Female Reproductive System Disease |
|
|
| Gastrointestinal System Cancer |
|
|
| Intermediate Coronary Syndrome |
|
|
| Gastrointestinal System Disease |
|
|
| Uterine Anomalies |
|
|
| Endometriosis Of Ovary |
|
|
| Cerebral Arterial Disease |
|
|
| Nasopharyngeal Disease |
|
|
| Cervix Disease |
|
|
| Bile Duct Disease |
|
|
| Urinary System Disease |
|
|
| Laryngeal Disease |
|
|
| Pharynx Cancer |
|
|
| Upper Respiratory Tract Disease |
|
|
| Bile Duct Cancer |
|
|
| Intestinal Disease |
|
|
| Respiratory System Disease |
|
|
| Biliary Tract Disease |
|
|
| Aortic Aneurysm |
|
|
| Tongue Disease |
|
|
| Central Nervous System Cancer |
|
|
| Gallbladder Disease |
|
|
| Ampulla Of Vater Cancer |
|
|
| Ovary Epithelial Cancer |
|
|
| Arteries, Anomalies Of |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Rectum Cancer |
|
|
| Aortic Disease |
|
|
| Bone Marrow Cancer |
|
|
| Endocrine System Disease |
|
|
| Cell Type Benign Neoplasm |
|
|
| Primary Cutaneous Amyloidosis |
|
|
| Biliary Atresia |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Endocrine Gland Cancer |
|
|
| Connective Tissue Cancer |
|
|
| Aortic Dissection |
|
|
| Head And Neck Cancer |
|
|
| Ovarian Disease |
|
|
| Choledocholithiasis |
|
|
| Prostate Disease |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Biliary Tract Cancer |
|
|
| Ampulla Of Vater Adenocarcinoma |
|
|
| Lymphatic System Disease |
|
|
| Spinal Disease |
|
|
| Leukocyte Disease |
|
|
| Lymphatic System Cancer |
|
|
| Esophageal Cancer |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Malignant Astrocytoma |
|
|
| Tongue Squamous Cell Carcinoma |
|
|
| Breast Disease |
|
|
| Pancreas Disease |
|
|
| Gallbladder Cancer |
|
|
| Colorectal Adenocarcinoma |
|
|
| Immune System Disease |
|
|
| Central Nervous System Disease |
|
|
| Bone Cancer |
|
|
| Papillary Serous Adenocarcinoma |
|
|
| Myocardial Infarction |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Inherited Metabolic Disorder |
|
|
| Lymph Node Disease |
|
|
| Large Cell Carcinoma |
|
|
| Cervix Small Cell Carcinoma |
|
|
| Glucose Metabolism Disease |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Cerebrovascular Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Neuroblastoma |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Hematologic Cancer |
|
|
| Kidney Cancer |
|
|
| Integumentary System Disease |
|
|
| Endometrial Cancer |
|
|
| Brain Cancer |
|
|
| Hypertension, Essential |
|
|
| Mouth Disease |
|
|
| Lung Disease |
|
|
| Retinal Disease |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Connective Tissue Disease |
|
|
| Nervous System Disease |
|
|
| Heart Conduction Disease |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Pancreatic Cancer |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| High Grade Glioma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Ovarian Cancer |
|
|
| Leukemia, Acute Myeloid |
|
|
| Osteoporosis |
|
|
| Cystic Fibrosis |
|
|
| Myeloma, Multiple |
|
|
| Colonic Benign Neoplasm |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR145 | RGD | RGD:2325565 |
| Mus musculus | MIR145 | MGD | MGI:2676830 |