MIR155 - microRNA 155 Gene
Also Known as MIRN155; mir-155; miRNA155
Species: Homo sapiens
About MIR155
This gene has 1 transcript (splice variant) and 80 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
27746237 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22815348 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
22815348 | GOA |
| acts upstream of negative regulation of cytokine production |
IDA
IDA: Inferred from direct assay
|
22815348 | GOA |
| involved in negative regulation of gene expression |
IDA
IDA: Inferred from direct assay
|
22815348 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Diffuse Large B-Cell Lymphoma |
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| Pancreatic Ductal Adenocarcinoma |
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| Dermatitis, Atopic |
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| Myeloproliferative Neoplasm |
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| Rheumatoid Arthritis |
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| Leukemia, Acute Lymphoblastic |
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| Lipoprotein Quantitative Trait Locus |
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| Hepatocellular Carcinoma |
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| Pancreatic Cancer |
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| Diabetes Mellitus |
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| Hypertension, Essential |
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| Breast Cancer |
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| Waldenstroem'S Macroglobulinemia |
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| Polymyositis |
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| Dermatomyositis |
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| Lymphoma, Hodgkin, Classic |
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| Down Syndrome |
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| Follicular Lymphoma |
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| Burkitt Lymphoma |
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| Inclusion Body Myositis |
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| Miyoshi Muscular Dystrophy 1 |
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| Facioscapulohumeral Muscular Dystrophy 1 |
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| Muscular Dystrophy, Duchenne Type |
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| Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1 |
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| Leukemia, Chronic Lymphocytic |
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| Nemaline Myopathy |
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| Squamous Cell Carcinoma, Head And Neck |
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| Leukemia, Acute Myeloid |
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| Glioblastoma |
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| Oral Squamous Cell Carcinoma |
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| Primary Mediastinal B-Cell Lymphoma |
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| Lung Cancer |
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| Autoimmune Disease Of Central Nervous System |
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| Ovarian Cancer |
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| Mature B-Cell Neoplasm |
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| Autoimmune Disease Of Musculoskeletal System |
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| Granulomatous Mastitis |
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| Colorectal Cancer |
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| Lymphatic System Cancer |
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| Lymphatic System Disease |
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| Immune System Disease |
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| Primary Bacterial Infectious Disease |
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| Mature T-Cell And Nk-Cell Lymphoma |
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| Connective Tissue Cancer |
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| Bone Inflammation Disease |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Integumentary System Disease |
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| Mycosis Fungoides |
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| Central Nervous System Cancer |
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| Larynx Cancer |
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| Chromosomal Duplication Syndrome |
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| Spinal Disease |
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| Arteriosclerosis |
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| Respiratory System Disease |
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| Chromosomal Disease |
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| Leukocyte Disease |
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| Chordoma |
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| Carbohydrate Metabolic Disorder |
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| Bronchopneumonia |
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| Malignant Astrocytoma |
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| Adult T-Cell Leukemia/Lymphoma |
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| Upper Respiratory Tract Disease |
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| Arteries, Anomalies Of |
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| Glucose Metabolism Disease |
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| Spinal Chordoma |
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| Inherited Metabolic Disorder |
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| Thoracic Cancer |
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| Laryngeal Disease |
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| Disease By Infectious Agent |
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| Infratentorial Cancer |
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| Acquired Metabolic Disease |
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| Hypersensitivity Reaction Type Iv Disease |
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| Intestinal Disease |
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| Bone Marrow Cancer |
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| Spinal Cord Disease |
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| Bronchial Disease |
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| Colonic Disease |
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| Urinary System Disease |
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| Respiratory System Cancer |
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| Leukemia, Acute Monocytic |
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| Gastrointestinal System Disease |
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| Fatty Liver Disease |
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| Central Nervous System Disease |
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| Borna Disease |
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| Large Intestine Cancer |
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| Overnutrition |
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| Renal Cell Carcinoma, Nonpapillary |
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| Endocrine Gland Cancer |
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| Lipid Storage Disease |
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| Gastrointestinal System Cancer |
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| Mastitis |
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| Secondary Progressive Multiple Sclerosis |
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| Cell Type Benign Neoplasm |
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| Bone Cancer |
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| Mantle Cell Lymphoma |
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| Sensory System Disease |
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| Low Grade Glioma |
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| Endocrine System Disease |
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| Pancreas Disease |
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| Non-Alcoholic Fatty Liver Disease |
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| Angioimmunoblastic T-Cell Lymphoma |
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| Toxoplasmosis |
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| Central Nervous System Benign Neoplasm |
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| Hematologic Cancer |
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| Demyelinating Disease |
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| Female Reproductive System Disease |
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| Reproductive System Disease |
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| Contact Dermatitis |
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| Cervix Disease |
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| Liver Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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| Ovarian Disease |
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
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| Nasopharyngeal Carcinoma |
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| Multiple Sclerosis |
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| Myocarditis |
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| Degenerative Disc Disease |
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| Mycobacterium Tuberculosis 1 |
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| Peripheral T-Cell Lymphoma |
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| Myocardial Infarction |
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| Breast Disease |
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| Coronavirus Infectious Disease |
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| Allergic Contact Dermatitis |
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| Cervical Cancer |
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| Nasopharyngeal Disease |
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| Pharynx Cancer |
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| Uterine Anomalies |
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| Male Reproductive Organ Cancer |
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| Retinal Disease |
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| Male Reproductive System Disease |
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| Retinal Cancer |
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| Disease Of Mental Health |
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| Lymphoma, Mucosa-Associated Lymphoid Type |
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| Medulloblastoma |
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| Ocular Cancer |
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| Cerebrovascular Disease |
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| Connective Tissue Disease |
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| Psoriasis |
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| Stomach Disease |
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| Bone Disease |
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| Brain Cancer |
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| Bacterial Infectious Disease |
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| Prostate Disease |
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| Interstitial Lung Disease |
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| Crescentic Glomerulonephritis |
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| Immune Deficiency Disease |
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| Acute Proliferative Glomerulonephritis |
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| Lysosomal Storage Disease |
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| Allergic Disease |
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| Viral Infectious Disease |
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| Nervous System Disease |
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| Asthma |
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| Mouth Disease |
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| Cardiovascular System Disease |
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| Sarcoidosis 1 |
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| High Grade Glioma |
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| Mental Depression |
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| Skin Disease |
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| Eye Disease |
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| Respiratory Failure |
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| Bladder Disease |
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| Systemic Lupus Erythematosus |
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| Plasma Cell Neoplasm |
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| Microphthalmia |
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| Leukemia, Chronic Myeloid |
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| Thrombocytopenia |
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| T-Cell Acute Lymphoblastic Leukemia |
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| Heart Disease |
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| Cystic Fibrosis |
|
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| Autism Spectrum Disorder |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Sezary'S Disease |
|
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| Myeloma, Multiple |
|
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| Type 2 Diabetes Mellitus |
|
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| Parkinson Disease, Late-Onset |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR155 | RGD | RGD:7489038 |
| Mus musculus | MIR155 | MGD | MGI:2676840 |