Znrf3 - zinc and ring finger 3 Gene

Also Known as Gm1167

Species: Mus musculus

Gene Type: protein coding
Gene ID: 407821

Summary

Predicted to enable Frizzled binding activity and ubiquitin protein Ligase activity. Involved in regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in vibrissa. Orthologous to human ZNRF3 (zinc and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Znrf3 Products (2)

mRNA Protein Name
NM_001080924.2 NP_001074393.1 E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor
NM_001290501.1 NP_001277430.1 E3 ubiquitin-protein ligase ZNRF3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24349440 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22895187 MGI
involved in regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
22575959 MGI
involved in regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22575959 MGI
involved in stem cell proliferation IMP
IMP: Inferred from mutant phenotype
22895187 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase ZNRF3

  • RING-type E3 ubiquitin transferase ZNRF3

  • zinc/RING finger protein 3

Znrf3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Znrf3 Q5SSZ7 RSPO1 Homo sapiens Q2MKA7
SPR
24349440
Cross
Znrf3 Q5SSZ7 RSPO1 Homo sapiens Q2MKA7
X-Ray Diffraction
24349440
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10810 QPH-FR Inhibitor 99.54% Unkown
HY-RS16185 ZNRF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17716 Znrf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24181 Znrf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Znrf3 NCBI NCBI:84133