BECN2 - beclin 2 Gene

Also Known as BECN1L1; BECN1P1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 441925

About BECN2

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,957,767-241,959,062 (from NCBI)

This gene has 1 transcript (splice variant), 173 orthologues and 1 paralogue.

Summary

Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2022]

BECN2 Products (1)

mRNA Protein Name
NM_001290693.1 NP_001277622.1 beclin-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23954414 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor catabolic process IMP
IMP: Inferred from mutant phenotype
23954414 GOA
acts upstream of or within G protein-coupled receptor catabolic process IPI
IPI: Inferred from physical interaction
23954414 GOA
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
23954414 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
23954414 GOA
acts upstream of or within endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
23954414 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
23954414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beclin-2

  • Beclin-1-like protein 1

BECN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BECN2 A8MW95 GPRASP1 Homo sapiens Q5JY77
Anti Tag CoIP
23954414
Intra
BECN2 A8MW95 GPRASP1 Homo sapiens Q5JY77
Y2H
23954414
Intra
BECN2 A8MW95 GPRASP1 Homo sapiens Q5JY77
Anti Bait CoIP
23954414
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01466 BECN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BECN2 VGNC VGNC:26464
Mus musculus BECN2 MGD MGI:2684950
Macaca mulatta BECN2 VGNC VGNC:106323
Rattus norvegicus BECN2 RGD RGD:1563293
Canis familiaris BECN2 VGNC VGNC:38428
Others BECN2 NCBI