GPRASP1 - G protein-coupled receptor associated sorting protein 1 Gene

Also Known as GASP; GASP1; GASP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9737

About GPRASP1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,651,483-102,659,083 (from NCBI)

This gene has 6 transcripts (splice variants), 126 orthologues and 11 paralogues. Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues.

Summary

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 Dopamine Receptor (DRD2), delta Opioid Receptor (OPRD1), beta-2 Adrenergic Receptor (ADRB2), D4 Dopamine Receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

GPRASP1 Products (4)

mRNA Protein Name
NM_001099410.2 NP_001092880.1 G-protein coupled receptor-associated sorting protein 1
NM_001099411.2 NP_001092881.1 G-protein coupled receptor-associated sorting protein 1
NM_001184727.2 NP_001171656.1 G-protein coupled receptor-associated sorting protein 1
NM_014710.5 NP_055525.3 G-protein coupled receptor-associated sorting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15086532 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor catabolic process IMP
IMP: Inferred from mutant phenotype
23954414 GOA
acts upstream of or within G protein-coupled receptor catabolic process IPI
IPI: Inferred from physical interaction
23954414 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
23954414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRASP1 Protein Structure

Arm_2

Arm_2: Armadillo-like (1151 - 1385)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1395 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor-associated sorting protein 1

GPRASP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPRASP1 Q5JY77 OPRD1 Homo sapiens P41143
Y2H
15086532
Intra
GPRASP1 Q5JY77 OPRD1 Homo sapiens P41143
Pull Down
15086532
Intra
GPRASP1 Q5JY77 BECN2 Homo sapiens A8MW95
Anti Tag CoIP
23954414
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11596 NOTA-Asp2-αvβ6L / Unkown
HY-RS05747 GPRASP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GPRASP1 RGD RGD:621343
Mus musculus GPRASP1 MGD MGI:1917418
Canis familiaris GPRASP1 VGNC VGNC:49803
Others GPRASP1 NCBI