CLEC1B - C-type lectin domain family 1 member B Gene

Also Known as CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51266

About CLEC1B

Cytogenetic location: 12p13.31-p13.2 Genomic coordinates (GRCh38): 12:9,993,075-10,001,899 (from NCBI)

This gene has 4 transcripts (splice variants), 365 orthologues and 23 paralogues. Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue.

Summary

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

CLEC1B Products (3)

mRNA Protein Name
NM_001099431.2 NP_001092901.1 C-type lectin domain family 1 member B isoform b
NM_001393342.1 NP_001380271.1 C-type lectin domain family 1 member B isoform a
NM_016509.4 NP_057593.3 C-type lectin domain family 1 member B isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17616532 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
18955485 GOA
Biological Process GO Annotation Evidence References Source
involved in signal transduction IDA
IDA: Inferred from direct assay
18955485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC1B Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (120 - 218)

  • 0
  • 100
  • 200
  • 229 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 1 member B

  • C-type lectin-like receptor 2

Recombinant CLEC1B Proteins

Cat. No. Product Name Accession Purity
HY-P75336 CLEC1B/CLEC-2 Protein, Human (HEK293, His, solution) Q9P126-1 (Q58-P229) ≥ 80%, as determined by reducing SDS-PAGE.

CLEC1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P84843 CLEC2 Antibody (YA4540) IHC-P, FC, ELISA Human
HY-P84843A CLEC2 Antibody (YA4540)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Bleeding Disorder, Platelet-Type, 11

  • BDPLT11

  • Glycoprotein Vi Deficiency

  • Gp Vi Deficiency

  • Platelet-Type Bleeding Disorder 11

  • Bleeding Diathesis Due To A Collagen Receptor Defect

  • Bleeding Diathesis Due To Glycoprotein Vi Deficiency

  • Platelet-Type Bleeding Disorder-11

  • Bleeding Disorder, Platelet Type 11

  • Hemorrhage
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Bladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Bladder

  • Epidermoid Carcinoma Of The Urinary Bladder

  • Carcinoma Squamous Cell Bladder
Blood Platelet Disease

  • Platelet Disorder

  • Blood Platelet Disorders

  • Thrombocytopathy

  • Platelet Dysfunction

  • Platelet Disorders

  • Qualitative Platelet Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02786 CLEC1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18087 Clec1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24561 Clec1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLEC1B RGD RGD:1563517
Felis catus CLEC1B VGNC VGNC:60946
Bos taurus CLEC1B VGNC VGNC:58366
Canis familiaris CLEC1B VGNC VGNC:49802
Macaca mulatta CLEC1B VGNC VGNC:71336
Mus musculus CLEC1B MGD MGI:1913287
Others CLEC1B NCBI