CLEC2 Antibody (YA4540)(PBS only)
(Synonyms: CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik)CLEC2 Antibody (YA4540) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CLEC2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CLEC2 Antibody (YA4540) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CLEC2.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 25 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 26.6 kDa
Purified recombinant fragment of human CLEC2 (AA: Extra(58-229)) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLEC2 is a C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2; (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2; (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets[1][2][3][4].
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Subcellular Localization
Membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets -
Isoforms & Post-Translational Modification
Q9P126 has 2 isomers: Q9P126-1: 26596 Da (predicted); Q9P126-2: 23096 Da (predicted).
Glycosylated;Phosphorylated on tyrosine residue in response to rhodocytin binding -
Subunit
Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains). Interacts with PDPN; the interaction is independent of CLEC1B glycosylation and activates CLEC1B (PubMed:18215137)
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SwissProt ID
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Synonyms
CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
Documentation
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