CLEC1B/CLEC-2 Protein, Human (HEK293, His, solution)
CLEC1B/CLEC-2 protein is a C-type lectin-like receptor that acts as a platelet receptor and snake venom protein receptor for PDPN in microbial infections. Upon activation, it initiates a signaling cascade involving SRC and SYK kinases, leading to PLCG2 activation. CLEC1B/CLEC-2 Protein, Human (HEK293, His, solution) is the recombinant human-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CLEC1B/CLEC-2 protein is a C-type lectin-like receptor that acts as a platelet receptor and snake venom protein receptor for PDPN in microbial infections. Upon activation, it initiates a signaling cascade involving SRC and SYK kinases, leading to PLCG2 activation. CLEC1B/CLEC-2 Protein, Human (HEK293, His, solution) is the recombinant human-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-His labeled tag.
Background
CLEC1B/CLEC-2 protein serves as a C-type lectin-like receptor with a notable function as a platelet receptor for the lymphatic endothelial marker, PDPN. Upon ligand activation, it initiates signaling cascades involving the sequential activation of SRC and SYK tyrosine kinases, ultimately leading to the activation of PLCG2. In the context of microbial infection, CLEC1B/CLEC-2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding induces tyrosine phosphorylation, facilitating the binding of spleen tyrosine kinase (SYK) and initiating downstream tyrosine phosphorylation events, along with the activation of PLCG2. This multifaceted role highlights the involvement of CLEC1B/CLEC-2 in platelet function and immune responses, particularly in the context of interactions with PDPN and rhodocytin.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-His
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Accession
Q9P126-1 (Q58-P229)
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Molecular Construction
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N-term
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His
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CLEC1B (Q58-P229)
Accession # Q9P126-1 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
CLEC1B; C-Type Lectin Domain Family 1, Member B; C-Type Lectin Domain Family 1 Member B; 1810061I13Rik; CLEC2; PRO1384; CLEC-2; QDED721; C-Type Lectin-Like Receptor 2
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AA Sequence
QRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP
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Predicted Molecular Mass
22.7 kDa
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Molecular Weight
Approximately 35-38 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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