KLRF1 - killer cell lectin like receptor F1 Gene

Also Known as NKp80; CLEC5C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51348

About KLRF1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,800,052-9,845,005 (from NCBI)

This gene has 8 transcripts (splice variants), 188 orthologues and 23 paralogues. Biased expression in spleen (RPKM 7.2), bone marrow (RPKM 3.9) and 10 other tissues.

Summary

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

KLRF1 Products (4)

mRNA Protein Name
NM_001291822.2 NP_001278751.1 killer cell lectin-like receptor subfamily F member 1 isoform KLRF1-s
NM_001291823.2 NP_001278752.1 killer cell lectin-like receptor subfamily F member 1 isoform KLRF1-s3
NM_001366534.1 NP_001353463.1 killer cell lectin-like receptor subfamily F member 1 isoform 2
NM_016523.3 NP_057607.1 killer cell lectin-like receptor subfamily F member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
17057721 GOA
Biological Process GO Annotation Evidence References Source
involved in NK T cell activation IDA
IDA: Inferred from direct assay
17057721 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRF1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (133 - 231)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

killer cell lectin-like receptor subfamily F member 1

  • C-type lectin domain family 5 member C

Recombinant KLRF1 Proteins

Cat. No. Product Name Accession Purity
HY-P72501 NKp80/KLRF1 Protein, Human (HEK293, His) Q9NZS2-1 (V66-Y231) ≥ 95%, as determined by reducing SDS-PAGE.

KLRF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85019 NKp80 Antibody (YA4711) ELISA, FC Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07396 KLRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLRF1 VGNC VGNC:63160
Bos taurus KLRF1 VGNC VGNC:30685
Canis familiaris KLRF1 VGNC VGNC:54318
Macaca mulatta KLRF1 VGNC VGNC:74042
Rattus norvegicus KLRF1 RGD RGD:1587563
Others KLRF1 NCBI