NKp80 Antibody (YA4711)
(Synonyms: NKp80; CLEC5C; NKp80 nanobody; )NKp80 Antibody (YA4711) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp80.
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Host:
Mouse
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Application:
ELISA, FC
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:5000-100000 | 1-2μg/Test |
Product Details
NKp80 Antibody (YA4711) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp80.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant Human NKp80
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NKp80 functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases[1].
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Subcellular Localization
Membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes -
Isoforms & Post-Translational Modification
Q9NZS2 has 4 isomers: Q9NZS2-1: 26563 Da (predicted); Q9NZS2-2: 21205 Da (predicted); Q9NZS2-3: 7251 Da (predicted); Q9NZS2-4: 9029 Da (predicted).
Phosphorylated on Tyr-7; this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity -
Subunit
Homodimer (PubMed:11265639). Interacts with CLEC2B (PubMed:17057721)
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SwissProt ID
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Synonyms
NKp80; CLEC5C; NKp80 nanobody;
Documentation
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