NKp80 Antibody (YA4711)

Cat. No.: HY-P85019: Data Sheet User Guide for Antibodies
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NKp80 Antibody (YA4711) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp80.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NKp80 Antibody (YA4711) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp80.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

Q9NZS2

Gene ID

51348 [NCBI]

Immunogen

Purified recombinant Human NKp80

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000
FC FC: Flow Cytometry	1-2μg/Test

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606)

Subcellular Localization：Membrane; Single-pass type II membrane protein

Expression：
Tissue_specificity:Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes

Isoforms & Post-Translational Modification：Q9NZS2 has 4 isomers: Q9NZS2-1: 26563 Da (predicted); Q9NZS2-2: 21205 Da (predicted); Q9NZS2-3: 7251 Da (predicted); Q9NZS2-4: 9029 Da (predicted).
Phosphorylated on Tyr-7; this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity

Subunit：Homodimer (PubMed:11265639). Interacts with CLEC2B (PubMed:17057721)

Synonyms

NKp80; CLEC5C; NKp80 nanobody;

Documentation

User Guide for Antibodies (1077 KB)