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SERPINI2 - serpin family I member 2 Gene

Also Known as MEPI; PI14; PANCPIN; TSA2004

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5276

About SERPINI2

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,441,933-167,476,963 (from NCBI)

This gene has 8 transcripts (splice variants), 104 orthologues and 36 paralogues. Restricted expression toward pancreas (RPKM 124.3).

Summary

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

SERPINI2 Products (3)

mRNA	Protein	Name
NM_001012303.3	NP_001012303.2	serpin I2 precursor
NM_001394327.1	NP_001381256.1	serpin I2 precursor
NM_006217.6	NP_006208.1	serpin I2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINI2 Protein Structure

Serpin

0
100
200
300
405 a.a.

Protein Preferred Names	Protein Names
serpin I2	myoepithelium-derived serine protease inhibitor

SERPINI2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	SERPINI2	O75830	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SERPINI2	O75830	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	16713569
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	SERPINI2	O75830	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	SERPINI2	O75830	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	SERPINI2	O75830	SGTB	Homo sapiens	Q96EQ0	Y2H	21516116
Intra	SERPINI2	O75830	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	SERPINI2	O75830	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	SERPINI2	O75830	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	SERPINI2	O75830	HPCAL1	Homo sapiens	P37235	Validated Y2H	32296183
Intra	SERPINI2	O75830	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	SERPINI2	O75830	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	SERPINI2	O75830	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SERPINI2	O75830	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71039	Serpin I2 Protein, Human (HEK293, His)	O75830 (S19-L405 )	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 61	RP61 Retinitis Pigmentosa, Type 61
Cardiomyopathy, Dilated, 1o	Dilated Cardiomyopathy 1o CMD1O Dilated Cardiomyopathy With Ventricular Tachycardia Cardiomyopathy, Dilated, With Ventricular Tachycardia Cardiomyopathy, Dilated 1o Cardiomyopathy, Dilated, Type 1o
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies	Familial Encephalopathy With Neuroserpin Inclusion Bodies FENIB Encephalopathy, Familial, With Collins Bodies Familial Dementia With Neuroserpin Inclusion Bodies Familial Encephalopathy With Collins Bodies
Corneal Dystrophy, Meesmann, 1	Meesmann Corneal Dystrophy Mecd Corneal Dystrophy, Meesmann Epithelial Juvenile Hereditary Epithelial Dystrophy Corneal Dystrophy, Juvenile Epithelial Of Meesmann MECD1 Meesmann Corneal Dystrophy 1 Meesmann Corneal Epithelial Dystrophy Meesmann Epithelial Corneal Dystrophy Corneal Dystrophy, Juvenile Epithelial, Of Meesmann Stocker-Holt Dystrophy Meesman Dystrophy Meesman'S Corneal Dystrophy Juvenile Hereditary Epithelial Dystrophy Of Meesmann Corneal Dystrophy, Meesmann 1 Juvenile Epithelial Corneal Dystrophy Of Meesmann Mcd Dystrophy, Corneal, Meesmann
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12730	SERPINI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20671	Serpini2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27182	Serpini2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERPINI2	MGD	MGI:1915181
Macaca mulatta	SERPINI2	VGNC	VGNC:77367
Canis familiaris	SERPINI2	VGNC	VGNC:46043
Felis catus	SERPINI2	VGNC	VGNC:68835
Bos taurus	SERPINI2	VGNC	VGNC:34482
Rattus norvegicus	SERPINI2	RGD	RGD:619897
Others	SERPINI2	NCBI