Hif3a - hypoxia inducible factor 3, alpha subunit Gene

Mus musculus

Also known as Ipas; MOP7; NEPAS; bHLHe17

Gene ID: 53417 | Gene type: protein coding

About Hif3a

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within response to hypoxia and transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; and lung. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hif3a Products(2)

mRNA	Protein	Name
NM_001162950.1	NP_001156422.1	hypoxia-inducible factor 3-alpha isoform 1
NM_016868.3	NP_058564.2	hypoxia-inducible factor 3-alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IPI IPI: Inferred from physical interaction	9840812	MGI
enables DNA-binding transcription factor activity	IPI IPI: Inferred from physical interaction	9840812	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21546903	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	9840812	MGI
acts upstream of or within transcription by RNA polymerase II	IPI IPI: Inferred from physical interaction	9840812	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21546903	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	21546903	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	21546903	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21546903	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hypoxia-inducible factor 3-alpha

HIF-3-alpha	HIF3-alpha
HIF3-alpha-1	basic-helix-loop-helix-PAS protein MOP7
hypoxia inducible factor three alpha	inhibitory PAS domain protein
member of PAS protein 7	neonatal and embryonic PAS protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06170	HIF3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hif3a	NCBI	NCBI:64344

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