Hif3a - hypoxia inducible factor 3, alpha subunit Gene

Also Known as Ipas; MOP7; NEPAS; bHLHe17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53417

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within response to hypoxia and transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; and lung. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hif3a Products (2)

mRNA Protein Name
NM_001162950.1 NP_001156422.1 hypoxia-inducible factor 3-alpha isoform 1
NM_016868.3 NP_058564.2 hypoxia-inducible factor 3-alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IPI
IPI: Inferred from physical interaction
9840812 MGI
enables DNA-binding transcription factor activity IPI
IPI: Inferred from physical interaction
9840812 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21546903 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
9840812 MGI
acts upstream of or within transcription by RNA polymerase II IPI
IPI: Inferred from physical interaction
9840812 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21546903 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
21546903 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
21546903 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21546903 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hypoxia-inducible factor 3-alpha

  • HIF-3-alpha

  • HIF3-alpha

  • HIF3-alpha-1

  • basic-helix-loop-helix-PAS protein MOP7

  • hypoxia inducible factor three alpha

  • inhibitory PAS domain protein

  • member of PAS protein 7

  • neonatal and embryonic PAS protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06170 HIF3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hif3a NCBI NCBI:64344