2. Gene
  3. Pitx2 - paired-like homeodomain 2 Gene

Pitx2 - paired-like homeodomain 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ptx2; Pitx-2; Pitx2c

Gene ID: 54284 | Gene type: protein coding

About Pitx2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and response to vitamin A. Located in nucleus. Biomarker of autosomal dominant polycystic kidney disease and hypothyroidism. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2). [provided by Alliance of Genome Resources, Apr 2022]

Pitx2 Products(2)

mRNA Protein Name
NM_001042505.1 NP_001035970.1 pituitary homeobox 2 isoform 1
NM_019334.2 NP_062207.1 pituitary homeobox 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11032870 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11032870 RGD
Biological Process GO Annotation Evidence Reference Source
involved in female gonad development IEP
IEP: Inferred from expression pattern
21325833 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
21325833 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
16408195 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
16416307 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11032870 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17982271 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
18955041 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary homeobox 2

homeobox protein PITX2

homeodomain transcription factor 2

paired-like homeodomain transcription factor 2

rPtx2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10582 PITX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22730 Pitx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pitx2 NCBI NCBI:5308