Pitx2 - paired-like homeodomain 2 Gene

Also Known as Ptx2; Pitx-2; Pitx2c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54284

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and response to vitamin A. Located in nucleus. Biomarker of autosomal dominant polycystic kidney disease and hypothyroidism. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2). [provided by Alliance of Genome Resources, Apr 2022]

Pitx2 Products (2)

mRNA Protein Name
NM_001042505.1 NP_001035970.1 pituitary homeobox 2 isoform 1
NM_019334.2 NP_062207.1 pituitary homeobox 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11032870 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11032870 RGD
Biological Process GO Annotation Evidence References Source
involved in female gonad development IEP
IEP: Inferred from expression pattern
21325833 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
21325833 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
16408195 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
16416307 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11032870 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17982271 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
18955041 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary homeobox 2

  • homeobox protein PITX2

  • homeodomain transcription factor 2

  • paired-like homeodomain transcription factor 2

  • rPtx2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10582 PITX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22730 Pitx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pitx2 NCBI NCBI:5308