PRKG1 - Prkg1 protein kinase cGMP-dependent 1 Gene

Also Known as Pkgi; cGk1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54286

Summary

Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; regulation of cellular biosynthetic process; and regulation of ion transport. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleoplasm. Colocalizes with sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Apr 2022]

PRKG1 Products (1)

mRNA Protein Name
NM_001105731.4 NP_001099201.3 cGMP-dependent protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23454089 RGD
enables mitogen-activated protein kinase p38 binding IDA
IDA: Inferred from direct assay
16943189 RGD
Biological Process GO Annotation Evidence References Source
involved in cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
19542178 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
15763176 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
2792381 RGD
involved in negative regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
10081919 RGD
involved in negative regulation of inositol phosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
7535379 RGD
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
15576431 RGD
involved in positive regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
12930792 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
8706897 RGD
involved in positive regulation of large conductance calcium-activated potassium channel activity IMP
IMP: Inferred from mutant phenotype
23407708 RGD
involved in regulation of testosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
22429315 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
15713832 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
8719784 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
15713832 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
18474265 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
12855709 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cGMP-dependent protein kinase 1

  • cAMP-dependent protein kinase catalytic subunit PRKX-like

  • cGMP dependent protein kinase type 1

  • protein kinase, cGMP-dependent, type 1

  • protein kinase, cGMP-dependent, type I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11154 PRKG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20087 Prkg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26590 Prkg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PRKG1 NCBI NCBI:5592