ZGRF1 - zinc finger GRF-type containing 1 Gene

Also Known as C4orf21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55345

About ZGRF1

This gene has 12 transcripts (splice variants) and 87 orthologues. Broad expression in bone marrow (RPKM 3.0), testis (RPKM 2.5) and 24 other tissues.

Summary

The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]

ZGRF1 Products (2)

mRNA	Protein	Name
NM_001350397.2	NP_001337326.1	protein ZGRF1 isoform 2
NM_018392.5	NP_060862.3	protein ZGRF1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-3' DNA helicase activity	IDA IDA: Inferred from direct assay	32640219	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32640219	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in recombinational repair	IDA IDA: Inferred from direct assay	32640219	GOA
involved in recombinational repair	IMP IMP: Inferred from mutant phenotype	32640219	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	32640219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein ZGRF1	GRF-type zinc finger domain-containing protein 1

ZGRF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	IF	34552057
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	Anti Tag CoIP	34552057
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	34552057
Intra	ZGRF1	Q86YA3	EXO1	Homo sapiens	Q9UQ84	Anti Bait CoIP	34552057
Intra	ZGRF1	Q86YA3	EXO1	Homo sapiens	Q9UQ84	Anti Tag CoIP	34552057

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood Apraxia Of Speech	Cas Articulatory Apraxia Das Developmental Apraxia Of Speech Developmental Verbal Apraxia Developmental Verbal Dyspraxia Speech And Language Disorder With Orofacial Dyspraxia Articulation Disorders, Developmental Apraxia, Articulatory Apraxia, Developmental Verbal
Scleral Staphyloma	Scleral Ectasia Staphyloma Of Sclera
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16067	ZGRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZGRF1	RGD	RGD:1305834
Mus musculus	ZGRF1	MGD	MGI:1918893