ACOT13 - acyl-CoA thioesterase 13 Gene

Also Known as HT012; THEM2; PNAS-27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55856

About ACOT13

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,667,077-24,705,046 (from NCBI)

This gene has 3 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 18.3), liver (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

ACOT13 Products (2)

mRNA Protein Name
NM_001160094.2 NP_001153566.1 acyl-coenzyme A thioesterase 13 isoform 2
NM_018473.4 NP_060943.1 acyl-coenzyme A thioesterase 13 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
16934754 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in protein homotetramerization IPI
IPI: Inferred from physical interaction
16934754 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT13 Protein Structure

4HBT

4HBT: Thioesterase superfamily (53 - 126)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

acyl-coenzyme A thioesterase 13

  • hotdog-fold thioesterase superfamily member 2

ACOT13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
ACOT13 Q9NPJ3 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACOT13 Proteins

Cat. No. Product Name Accession Purity
HY-P7452 ACOT13 Protein, Human (HEK293, His) Q9NPJ3-1 (T2-N140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Dyslexia
Reading Disorder

  • Specific Reading Disorder

  • Reading

  • Dyslexia

  • Developmental Reading Disorder
Learning Disability

  • Learning Disabilities

  • Learning Disorders

  • Academic Skill Disorder

  • Learning Disorder
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00176 ACOT13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19497 Acot13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25991 Acot13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ACOT13 VGNC VGNC:37518
Macaca mulatta ACOT13 VGNC VGNC:69487
Mus musculus ACOT13 MGD MGI:1914084
Bos taurus ACOT13 VGNC VGNC:25549
Felis catus ACOT13 VGNC VGNC:102373
Rattus norvegicus ACOT13 RGD RGD:1306513
Others ACOT13 NCBI