Slc2a8 - solute carrier family 2, (facilitated glucose transporter), member 8 Gene

Mus musculus

Also known as GLUT8; GlutX1; D2Ertd44e

Gene ID: 56017 | Gene type: protein coding

About Slc2a8

Summary

Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and hexose transmembrane transporter activity. Involved in dehydroascorbic acid transport; fructose transmembrane transport; and glucose transmembrane transport. Acts upstream of or within Insulin Receptor signaling pathway and response to hypoxia. Is integral component of plasma membrane. Is expressed in several structures, including adipose tissue; gut; liver; placenta; and spleen. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a8 Products(2)

mRNA	Protein	Name
NM_001356409.1	NP_001343338.1	solute carrier family 2, facilitated glucose transporter member 8 isoform 2
NM_019488.5	NP_062361.1	solute carrier family 2, facilitated glucose transporter member 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose binding	IDA IDA: Inferred from direct assay	10821868	MGI
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	10821868	MGI
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	23396969	MGI
enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	23396969	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	10821868	MGI
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	23396969	MGI
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	23396969	MGI
involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	23396969	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	10860996	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	11689004	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10821868	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 8

GLUT-8	glucose transporter X1
glucose transporter type 8	glucose transporter type X1
intestinal GLUT8 transporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139047	SW157765	Inhibitor	98.08%	Unkown
HY-RS13176	SLC2A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990674	VB1-050	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a8	NCBI	NCBI:29988

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