Srcin1 - SRC kinase signaling inhibitor 1 Gene

Rattus norvegicus

Also known as P140; Snip; p140Cap

Gene ID: 56029 | Gene type: protein coding

About Srcin1

Summary

Enables protein domain specific binding activity. Involved in negative regulation of protein secretion. Located in several cellular components, including filopodium; lamellipodium; and postsynaptic density. Orthologous to human SRCIN1 (Src kinase signaling inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Srcin1 Products(3)

mRNA	Protein	Name
NM_001393740.1	NP_001380669.1	SRC kinase signaling inhibitor 1 isoform 1
NM_001393741.1	NP_001380670.1	SRC kinase signaling inhibitor 1 isoform 3
NM_019378.2	NP_062251.1	SRC kinase signaling inhibitor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10625663	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	10625663	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	10625663	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10625663	RGD
located in axon	IDA IDA: Inferred from direct assay	18662323	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18662323	RGD
located in filopodium	IDA IDA: Inferred from direct assay	10625663	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	10625663	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10625663	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18662323	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	19146815	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	18662323	RGD
located in synapse	IDA IDA: Inferred from direct assay	18662323	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SRC kinase signaling inhibitor 1

SNAP25-interacting protein

p130Cas-associated protein

Srcin1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Srcin1	Q9QXY2	Snap25	Rattus norvegicus	P60881	Pull Down	10625663
Intra	Srcin1	Q9QXY2	Snap25	Rattus norvegicus	P60881	Confocal	10625663

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16905	T338C Src-IN-1	Inhibitor	/	Unkown
HY-RS13753	SRCIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srcin1	NCBI	NCBI:80725

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