Srcin1 - SRC kinase signaling inhibitor 1 Gene

Also Known as P140; Snip; p140Cap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56029

Summary

Enables protein domain specific binding activity. Involved in negative regulation of protein secretion. Located in several cellular components, including filopodium; lamellipodium; and postsynaptic density. Orthologous to human SRCIN1 (Src kinase signaling inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Srcin1 Products (3)

mRNA Protein Name
NM_001393740.1 NP_001380669.1 SRC kinase signaling inhibitor 1 isoform 1
NM_001393741.1 NP_001380670.1 SRC kinase signaling inhibitor 1 isoform 3
NM_019378.2 NP_062251.1 SRC kinase signaling inhibitor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10625663 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
10625663 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
10625663 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10625663 RGD
located in axon IDA
IDA: Inferred from direct assay
18662323 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18662323 RGD
located in filopodium IDA
IDA: Inferred from direct assay
10625663 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
10625663 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10625663 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
18662323 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
19146815 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
18662323 RGD
located in synapse IDA
IDA: Inferred from direct assay
18662323 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SRC kinase signaling inhibitor 1

  • SNAP25-interacting protein

  • p130Cas-associated protein

Srcin1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Srcin1 Q9QXY2 Snap25 Rattus norvegicus P60881
Pull Down
10625663
Intra
Srcin1 Q9QXY2 Snap25 Rattus norvegicus P60881
Confocal
10625663
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16905 T338C Src-IN-1 Inhibitor / Unkown
HY-RS13753 SRCIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srcin1 NCBI NCBI:80725