Dstn - destrin Gene

Also Known as ADF; Dsn; corn1; sid23p; 2610043P17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56431

Summary

Enables actin filament binding activity. Involved in actin filament fragmentation. Acts upstream of or within positive regulation of actin filament depolymerization. Located in cortical actin Cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Apr 2022]

Dstn Products (1)

mRNA Protein Name
NM_019771.2 NP_062745.1 destrin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11809832 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
11809832 MGI
involved in actin filament fragmentation IDA
IDA: Inferred from direct assay
11809832 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
15548599 MGI
acts upstream of or within cytokinesis IMP
IMP: Inferred from mutant phenotype
15548599 MGI
acts upstream of or within positive regulation of actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
15548599 MGI
Cellular Component GO Annotation Evidence References Source
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15548599 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15548599 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22046357 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
22046357 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
22046357 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

destrin

  • actin-depolymerizing factor

  • corneal disease 1

  • sid 23

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04029 DSTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dstn NCBI NCBI:11034