PANX2 - pannexin 2 Gene

Also Known as PX2; hPANX2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56666

About PANX2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,170,731-50,180,295 (from NCBI)

This gene has 3 transcripts (splice variants), 190 orthologues and 2 paralogues. Broad expression in brain (RPKM 3.4), kidney (RPKM 1.1) and 16 other tissues.

Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

PANX2 Products (2)

mRNA Protein Name
NM_001160300.2 NP_001153772.1 pannexin-2 isoform 2
NM_052839.4 NP_443071.2 pannexin-2 isoform 1

PANX2 Protein Structure

Innexin

Innexin: Innexin (50 - 253)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
Protein Preferred Names Protein Names

pannexin-2

PANX2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810268 Pannexin-2 Antibody (YA9612) WB, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Vasculogenic Impotence

  • Impotence, Vasculogenic
Oculodentodigital Dysplasia

  • Odd Syndrome

  • ODDD

  • Oculodentoosseous Dysplasia

  • Oculodentodigital Syndrome

  • Odod

  • Oculo-Dento-Digital Dysplasia

  • Oculo-Dento-Digital Syndrome

  • Oculo-Dento-Osseous Dysplasia

  • Osseous-Oculo-Dental Dysplasia

  • Meyer-Schwickerath Syndrome

  • Oddd Syndrome

  • Oculo Dento Digital Dysplasia

  • Odds

  • Oculodentodigital Dysplasia Syndrome
Gaucher Disease, Type Ii

  • GD2

  • Gd Ii

  • Gaucher Disease, Acute Neuronopathic Type

  • Gaucher Disease Type 2

  • Gaucher Disease Type Ii

  • Gaucher'S Disease Type Ii

  • Infantile Cerebral Gaucher Disease

  • Acute Neuronopathic Gaucher Disease

  • Gd 2

  • Gaucher Disease, Infantile Cerebral

  • Gaucher Disease 2

  • Type 2 Gaucher Disease

  • Gaucher Disease, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0170 Trovafloxacin Inhibitor 99.43% Unkown
HY-103399 Trovafloxacin mesylate Inhibitor 99.76% Unkown

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10022 PANX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PANX2 VGNC VGNC:75755
Rattus norvegicus PANX2 RGD RGD:735191
Mus musculus PANX2 MGD MGI:1890615
Canis familiaris PANX2 VGNC VGNC:44255
Bos taurus PANX2 VGNC VGNC:32568
Others PANX2 NCBI