PANX2 - pannexin 2 Gene

Homo sapiens

Also known as PX2; hPANX2

Gene ID: 56666 | Gene type: protein coding

About PANX2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,170,731-50,180,295 (from NCBI)

This gene has 3 transcripts (splice variants), 190 orthologues and 2 paralogues. Broad expression in brain (RPKM 3.4), kidney (RPKM 1.1) and 16 other tissues.

Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

PANX2 Products(2)

mRNA	Protein	Name
NM_001160300.2	NP_001153772.1	pannexin-2 isoform 2
NM_052839.4	NP_443071.2	pannexin-2 isoform 1

PANX2 Protein Structure

Innexin

0
200
400
600
677 a.a.

Protein Preferred Names

Protein Names

pannexin-2

Related Diseases

Diseases

Alias

Vasculogenic Impotence

Impotence, Vasculogenic

Oculodentodigital Dysplasia

Odd Syndrome	ODDD
Oculodentoosseous Dysplasia	Oculodentodigital Syndrome
Odod	Oculo-Dento-Digital Dysplasia
Oculo-Dento-Digital Syndrome	Oculo-Dento-Osseous Dysplasia
Osseous-Oculo-Dental Dysplasia	Meyer-Schwickerath Syndrome
Oddd Syndrome	Oculo Dento Digital Dysplasia
Odds	Oculodentodigital Dysplasia Syndrome

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103399	Trovafloxacin mesylate	Inhibitor	99.56%	Unkown
HY-A0170	Trovafloxacin		98.99%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10022	PANX2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PANX2	VGNC	VGNC:75755
Rattus norvegicus	PANX2	RGD	RGD:735191
Mus musculus	PANX2	MGD	MGI:1890615
Canis familiaris	PANX2	VGNC	VGNC:44255
Bos taurus	PANX2	VGNC	VGNC:32568

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