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Pannexin-2 Antibody (YA9612)

(Synonyms: hPANX2, pannexin 2, PANX2, PX2)
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Pannexin-2 Antibody (YA9612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pannexin-2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, IP, ELISA

  • Reactivity :

    human, mouse, rat

  • Formulation:

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1000 1-2μg per 100-500μg Total protein 1:50-3000

Product Details

Description

Pannexin-2 Antibody (YA9612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pannexin-2.

  • Host Mouse
  • Species Reactivity
    human, mouse, rat
  • Calculated Molecular Weight Predicted band size: 70 kDa
Species Reactivity Database

OMIM: 608421

Immunogen

A synthesized peptide derived from human Pannexin-2.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at 2-8°C for 1 year, do not freeze.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Pannexin-2 is an Ion channel with a slight anion preference. Also able to release ATP. Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity)[1][2].

  • Subcellular Localization

    Cell membrane; Golgi apparatus membrane; Endoplasmic reticulum membrane

  • Isoforms & Post-Translational Modification

    Pannexin-2 has 3 isoforms, Q96RD6-3: amino acid length is 677, molecular weight is 74447 Da (predicted); Q96RD6-1: amino acid length is 643, molecular weight is 70641 Da (predicted); Q96RD6-2: amino acid length is 509, molecular weight is 55733 Da (predicted).S-palmitoylated in neural stem and progenitor cells

  • Subunit

    Homoheptameric

  • SwissProt ID

    Q96RD6

  • Gene ID
    56666 [NCBI]
  • Synonyms

    hPANX2, pannexin 2, PANX2, PX2

References

[1]. He Z, et al. Structural and functional analysis of human pannexin 2 channel. Nat Commun. 2023 Mar 27;14(1):1712. [Content Brief]

[2]. Zhang H, et al. Cryo-EM structure of human heptameric pannexin 2 channel. Nat Commun. 2023 Mar 3;14(1):1118. [Content Brief]

Pannexin-2 Antibody (YA9612) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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