PCNP - PEST proteolytic signal containing nuclear protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57092

About PCNP

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,574,094-101,594,465 (from NCBI)

This gene has 8 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in ovary (RPKM 78.0), thyroid (RPKM 65.5) and 25 other tissues.

Summary

Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

PCNP Products (7)

mRNA Protein Name
NM_001320395.1 NP_001307324.1 PEST proteolytic signal-containing nuclear protein isoform b
NM_001320397.1 NP_001307326.1 PEST proteolytic signal-containing nuclear protein isoform c
NM_001320398.1 NP_001307327.1 PEST proteolytic signal-containing nuclear protein isoform d
NM_001320399.1 NP_001307328.1 PEST proteolytic signal-containing nuclear protein isoform e
NM_001320400.1 NP_001307329.1 PEST proteolytic signal-containing nuclear protein isoform f
NM_001320401.1 NP_001307330.1 PEST proteolytic signal-containing nuclear protein isoform g
NM_020357.3 NP_065090.1 PEST proteolytic signal-containing nuclear protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12176013 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14741369 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
14741369 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12176013 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCNP Protein Structure

PCNP

PCNP: PEST, proteolytic signal-containing nuclear protein family (22 - 167)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

PEST proteolytic signal-containing nuclear protein

  • PEST-containing nuclear protein

PCNP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
PCNP Q8WW12 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
PCNP Q8WW12 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Venezuelan Hemorrhagic Fever

  • Guanarito Hemorrhagic Fever

  • Vehf - [Venezuelan Haemorrhagic Fever]
Hereditary Lymphedema I

  • Lymphedema

  • Hereditary Lymphedema Type I

  • Congenital Primary Lymphedema

  • Lmph1

  • Milroy Disease

  • Nonne-Milroy Lymphedema

  • Pcl

  • Lymphedema Hereditary Type 1
Hereditary Lymphedema

  • Milroy Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11060 MC38 SLP Adpgk 97.52% Unkown
HY-RS10160 PCNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCNP RGD RGD:1563775
Bos taurus PCNP VGNC VGNC:32636
Felis catus PCNP VGNC VGNC:102801
Canis familiaris PCNP VGNC VGNC:44311
Mus musculus PCNP MGD MGI:1923552
Macaca mulatta PCNP VGNC VGNC:84059
Others PCNP NCBI