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Piwil2 - piwi-like RNA-mediated gene silencing 2 Gene

Also Known as mili; Piwil1l

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57746

Summary

Enables RNA binding activity; endoribonuclease activity; and polysome binding activity. Involved in several processes, including germ-line stem cell population maintenance; nucleic acid metabolic process; and positive regulation of cellular protein metabolic process. Acts upstream of or within oogenesis and positive regulation of meiosis I. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dense body; and perinucleolar chromocenter. Part of PET complex. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2). [provided by Alliance of Genome Resources, Apr 2022]

Piwil2 Products (2)

mRNA	Protein	Name
NM_001364321.1	NP_001351250.1	piwi-like protein 2 isoform 2
NM_021308.2	NP_067283.1	piwi-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	28633017	MGI
enables RNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	22020280	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	19114715	MGI
enables piRNA binding	IDA IDA: Inferred from direct assay	16751777	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16787967	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in germ-line stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19114715	MGI
involved in negative regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	28903391	MGI
involved in oogenesis	IEP IEP: Inferred from expression pattern	18404146	MGI
acts upstream of or within pachytene	IGI IGI: Inferred from genetic interaction	21539824	MGI
acts upstream of or within pachytene	IMP IMP: Inferred from mutant phenotype	21539824	MGI
involved in piRNA processing	IDA IDA: Inferred from direct assay	17446352	MGI
involved in piRNA processing	IMP IMP: Inferred from mutant phenotype	22020280	MGI
involved in piRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	29437694	MGI
acts upstream of positive effect piRNA-mediated retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	23706823	MGI
involved in positive regulation of cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	19114715	MGI
acts upstream of or within positive regulation of meiosis I	IMP IMP: Inferred from mutant phenotype	14736746	MGI
involved in regulatory ncRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	17446352	MGI
acts upstream of positive effect retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	22020280	MGI
involved in retrotransposon silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	18922463	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IMP IMP: Inferred from mutant phenotype	18381894	MGI
involved in secondary piRNA processing	IDA IDA: Inferred from direct assay	18922463	MGI
involved in secondary piRNA processing	IMP IMP: Inferred from mutant phenotype	29437694	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	18381894	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P granule	IDA IDA: Inferred from direct assay	18922463	MGI
part of PET complex	IDA IDA: Inferred from direct assay	26669262	MGI
located in chromatoid body	IDA IDA: Inferred from direct assay	19114715	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19114715	MGI
located in dense body	IDA IDA: Inferred from direct assay	21539824	MGI
located in nucleus	IDA IDA: Inferred from direct assay	27856912	MGI
located in perinucleolar chromocenter	IDA IDA: Inferred from direct assay	21539824	MGI
located in pi-body	IDA IDA: Inferred from direct assay	19730684	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
piwi-like protein 2	Miwi like Miwi likw piwi-like homolog 2

Piwil2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Piwil2	Q8CDG1	Tdrd1	Mus musculus	Q99MV1	Pull Down	19465913
Intra	Piwil2	Q8CDG1	Tdrd1	Mus musculus	Q99MV1	Anti Tag CoIP	19465913
Intra	Piwil2	Q8CDG1	Tdrd1	Mus musculus	Q99MV1	Anti Bait CoIP	19465913

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10585	PIWIL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Piwil2	NCBI	NCBI:55124