Tnip1 - TNFAIP3 interacting protein 1 Gene

Mus musculus

Also known as Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1

Gene ID: 57783 | Gene type: protein coding

About Tnip1

Summary

Enables polyubiquitin modification-dependent protein binding activity. Involved in several processes, including MyD88-dependent Toll-like Receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of inflammatory response. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tnip1 Products(5)

mRNA	Protein	Name
NM_001199275.2	NP_001186204.1	TNFAIP3-interacting protein 1 isoform 1
NM_001199276.2	NP_001186205.1	TNFAIP3-interacting protein 1 isoform 2
NM_001271455.1	NP_001258384.1	TNFAIP3-interacting protein 1 isoform 2
NM_001271456.1	NP_001258385.1	TNFAIP3-interacting protein 1 isoform 3
NM_021327.4	NP_067302.2	TNFAIP3-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	18212736	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10385526	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in MyD88-dependent toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	22011580	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18212736	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22011580	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22011580	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10385526	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNFAIP3-interacting protein 1

A20-binding inhibitor of NF-kappa B activation	Nef-associated factor 1
virion-associated nuclear shuttling protein

Tnip1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tnip1	Q9WUU8	Tnfaip3	Mus musculus	Q60769	Anti Tag CoIP	19060883
Intra	Tnip1	Q9WUU8	Tnfaip3	Mus musculus	Q60769	Anti Tag CoIP	12586352

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14834	TNIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnip1	NCBI	NCBI:10318

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