Tnip1 - TNFAIP3 interacting protein 1 Gene

Also Known as Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57783

Summary

Enables polyubiquitin modification-dependent protein binding activity. Involved in several processes, including MyD88-dependent Toll-like Receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of inflammatory response. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tnip1 Products (5)

mRNA Protein Name
NM_001199275.2 NP_001186204.1 TNFAIP3-interacting protein 1 isoform 1
NM_001199276.2 NP_001186205.1 TNFAIP3-interacting protein 1 isoform 2
NM_001271455.1 NP_001258384.1 TNFAIP3-interacting protein 1 isoform 2
NM_001271456.1 NP_001258385.1 TNFAIP3-interacting protein 1 isoform 3
NM_021327.4 NP_067302.2 TNFAIP3-interacting protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18212736 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10385526 MGI
Biological Process GO Annotation Evidence References Source
involved in MyD88-dependent toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
22011580 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
18212736 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22011580 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22011580 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10385526 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNFAIP3-interacting protein 1

  • A20-binding inhibitor of NF-kappa B activation

  • Nef-associated factor 1

  • virion-associated nuclear shuttling protein

Tnip1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tnip1 Q9WUU8 Tnfaip3 Mus musculus Q60769
Anti Tag CoIP
19060883
Intra
Tnip1 Q9WUU8 Tnfaip3 Mus musculus Q60769
Anti Tag CoIP
12586352
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14834 TNIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnip1 NCBI NCBI:10318