Rad18 - RAD18 E3 ubiquitin protein ligase Gene

Also Known as Rad18sc; 2810024C04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58186

Summary

Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including negative regulation of DNA recombination; response to UV; and spermatogenesis. Located in XY body; chromatin; and nucleus. Is expressed in adrenal medulla; dorsal root ganglion; testis; trunk mesenchyme derived from neural crest; and urinary system. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Rad18 Products (5)

mRNA Protein Name
NM_001167730.1 NP_001161202.1 E3 ubiquitin-protein ligase RAD18 isoform 1
NM_001381931.1 NP_001368860.1 E3 ubiquitin-protein ligase RAD18 isoform 3
NM_001381932.1 NP_001368861.1 E3 ubiquitin-protein ligase RAD18 isoform 4
NM_001381933.1 NP_001368862.1 E3 ubiquitin-protein ligase RAD18 isoform 5
NM_021385.2 NP_067360.2 E3 ubiquitin-protein ligase RAD18 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12509447 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
12509447 MGI
acts upstream of or within negative regulation of DNA recombination IMP
IMP: Inferred from mutant phenotype
12509447 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
12509447 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
19068231 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
15383616 MGI
located in chromatin IDA
IDA: Inferred from direct assay
15657431 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
19068231 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11013078 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RAD18

  • RAD18 homolog

  • RING-type E3 ubiquitin transferase RAD18

  • mRAD18Sc

  • post-replication repair protein RAD18SC

  • postreplication repair protein RAD18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11621 JWP24 Inhibitor / Unkown
HY-RS11598 RAD18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad18 NCBI NCBI:56852