DLGAP3 - DLG associated protein 3 Gene

Also Known as DAP3; SAPAP3; SPAPA3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 58512

About DLGAP3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:34,865,436-34,929,650 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 4 paralogues. Biased expression in brain (RPKM 6.5) and testis (RPKM 1.3).

Summary

Predicted to enable PDZ domain binding activity; molecular adaptor activity; and scaffold protein binding activity. Predicted to be involved in protein-containing complex assembly and regulation of postsynaptic neurotransmitter receptor activity. Predicted to be located in synapse. Predicted to be part of postsynaptic density. Predicted to be active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP3 Products (1)

mRNA	Protein	Name
NM_001080418.3	NP_001073887.1	disks large-associated protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP3 Protein Structure

GKAP

0
200
400
600
800
979 a.a.

Protein Preferred Names	Protein Names
disks large-associated protein 3	DAP-3

DLGAP3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DLGAP3	O95886	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	DLGAP3	O95886	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	DLGAP3	O95886	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	DLGAP3	O95886	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	DLGAP3	O95886	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	DLGAP3	O95886	MAGI2	Homo sapiens	Q86UL8-2	Validated Y2H	32296183
Intra	DLGAP3	O95886	MAGI2	Homo sapiens	Q86UL8-2	Y2H Array	32296183
Intra	DLGAP3	O95886	MAGI2	Homo sapiens	Q86UL8-2	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	DLGAP3	O95886	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	DLGAP3	O95886	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	DLGAP3	O95886	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	DLGAP3	O95886	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	DLGAP3	O95886	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	DLG2	Homo sapiens	Q15700	Y2H Prey Pooling	32296183
Intra	DLGAP3	O95886	DLG2	Homo sapiens	Q15700	Validated Y2H	32296183
Intra	DLGAP3	O95886	DLG2	Homo sapiens	Q15700	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Kleptomania	Pathological Stealing
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Tic Disorder	Tics Behavioral Tic
Chronic Tic Disorder	Chronic Motor Or Vocal Tic Disorder Tic Disorders Tic Disorder Tic Disorder Nos Tic Nos Tic Spasm Nos
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Follicular Mucinosis	Alopecia Mucinosa Mucinosis, Follicular
Dicarboxylic Aminoaciduria	Glutamate-Aspartate Transport Defect Dicarboxylicaminoaciduria DCBXA Renal Aminoacidurias
Transient Tic Disorder
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Syndromic Intellectual Disability
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03803	DLGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	DLGAP3	VGNC	VGNC:28089
Mus musculus	DLGAP3	MGD	MGI:3039563
Macaca mulatta	DLGAP3	VGNC	VGNC:71998
Felis catus	DLGAP3	VGNC	VGNC:61515
Canis familiaris	DLGAP3	VGNC	VGNC:39981
Rattus norvegicus	DLGAP3	RGD	RGD:708349
Others	DLGAP3	NCBI